Title :

Autoimmune hepatitis recurrence after liver transplantation: \"Les jeux sont faits\".

Author(s) :

Chouik, Yasmina [Auteur]
Hôpital Edouard Herriot [CHU - HCL]
Hôpital de la Croix-Rousse [CHU - HCL]
Corpechot, Christophe [Auteur]
Centre de Recherche Saint-Antoine [CRSA]
Francoz, Claire [Auteur]
Hôpital Beaujon [AP-HP]
De Martin, Eleonora [Auteur]
Centre Hépato-Biliaire [Hôpital Paul Brousse] [CHB]
Guillaud, Olivier [Auteur]
Hôpital Edouard Herriot [CHU - HCL]
Abergel, Armand [Auteur]
CHU Estaing [Clermont-Ferrand]
Altieri, Mario [Auteur]
Hôpital Côte de Nacre [CHU Caen]
Barbier, Louise [Auteur]
CHU Trousseau [APHP]
Besch, Camille [Auteur]
Hôpital de Hautepierre [Strasbourg]
Chazouillères, Olivier [Auteur]
Centre de Recherche Saint-Antoine [CRSA]
Conti, Filomena [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Dharancy, Sebastien [Auteur]
Hôpital Claude Huriez [Lille]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Durand, François [Auteur]
Hôpital Beaujon [AP-HP]
Duvoux, Christophe [Auteur]
CHU Henri Mondor [Créteil]
Gugenheim, Jean [Auteur]
Centre Hospitalier Universitaire de Nice [CHU Nice]
Hardwigsen, Jean [Auteur]
Hôpital de la Timone [CHU - APHM] [TIMONE]
Hilleret, Marie-Noëlle [Auteur]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Houssel-Debry, Pauline [Auteur]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Kamar, Nassim [Auteur]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]
Minello, Anne [Auteur]
Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand [CHU Dijon]
Neau-Cransac, Martine [Auteur]
Hôpital Haut-Lévêque [CHU Bordeaux]
Pageaux, Georges-Philippe [Auteur]
Hôpital Saint Eloi [CHU Montpellier]
Radenne, Sylvie [Auteur]
Hôpital de la Croix-Rousse [CHU - HCL]
Roux, Olivier [Auteur]
Hôpital Beaujon [AP-HP]
Saliba, Faouzi [Auteur]
Hôpital Paul Brousse
Samuel, Didier [Auteur]
Hôpital Paul Brousse
Vanlemmens, Claire [Auteur]
Hôpital JeanMinjoz
Woehl-Jaegle, Marie-Lorraine [Auteur]
Hôpital de Hautepierre [Strasbourg]
Leroy, Vincent [Auteur]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Duclos-Vallée, Jean-Charles [Auteur]
Hôpital Paul Brousse
Dumortier, Jerome [Auteur]
Hôpital Edouard Herriot [CHU - HCL]

Journal title :

Liver Transplantation

Abbreviated title :

Liver Transpl

Publication date :

2023-10-05

ISSN :

1527-6473

English abstract : [en]

Autoimmune hepatitis (AIH) may recur after liver transplantation (LT). The aims of this study were to evaluate the incidence and risk factors for recurrent autoimmune hepatitis (rAIH). A multicenter retrospective French ...
Show more >Autoimmune hepatitis (AIH) may recur after liver transplantation (LT). The aims of this study were to evaluate the incidence and risk factors for recurrent autoimmune hepatitis (rAIH). A multicenter retrospective French nationwide study, including all patients aged ≥16 transplanted for AIH, with at least 1 liver biopsy 1 year after LT, was conducted between 1985 and 2018. Risk factors for rAIH were identified using a multivariate Cox regression model. Three hundred and forty-four patients were included (78.8% women) with a median age at LT of 43.6 years. Seventy-six patients (22.1%) developed recurrence in a median time of 53.6 months (IQR, 14.1–93.2). Actuarial risk for developing rAIH was 41.3% 20 years after LT. In multivariate analysis, the strongest risk factor for rAIH was cytomegalovirus D+/R− mismatch status (HR=2.0; 95% CI: 1.1–3.6; p=0.03), followed by associated autoimmune condition. Twenty-one patients (27.6% of rAIH patients) developed liver graft cirrhosis after rAIH. Independent risk factors for these severe forms of rAIH were young age at LT, IgG levels >20.7 g/L, and LT in the context of (sub)fulminant hepatitis. Immunosuppression, especially long-term maintenance of corticosteroid therapy, was not significantly associated with rAIH. Recurrence of AIH after LT is frequent and may lead to graft loss. Recurrence is more frequent in young patients with active disease at the time of LT, yet systematic corticosteroid therapy does not prevent it.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-02-03T22:19:30Z
2024-03-12T11:08:30Z