Can we predict the risk of esophageal stricture after caustic injury?

Type de document :

Article dans une revue scientifique: Article original

DOI :

10.1093/dote/doae001

PMID :

URL permanente :

http://hdl.handle.net/20.500.12210/106918

Titre :

Can we predict the risk of esophageal stricture after caustic injury?

Auteur(s) :

Zerbib, Philippe [Auteur]

Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Lailheugue, Aurore [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Labreuche, Julien [Auteur]
Service de Biostatistiques [CHRU Lille]
Richa, Yasmina [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Cailliau, Emeline [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Onimus, Thierry [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Valibouze, Caroline [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]

Titre de la revue :

Diseases of the Esophagus

Nom court de la revue :

Dis Esophagus

Date de publication :

2024-01-29

ISSN :

1442-2050

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Nonoperative management of severe caustic injuries has demonstrated its feasibility, avoiding the need for emergency esogastric resection and resulting in low mortality rates. However, leaving superficial necrosis in place ...
Lire la suite >Nonoperative management of severe caustic injuries has demonstrated its feasibility, avoiding the need for emergency esogastric resection and resulting in low mortality rates. However, leaving superficial necrosis in place could increase the risk of esophageal stricture development. Data on the risk factors of esophageal stricture secondary to caustic ingestion are scarce. The aim of our study was to identify the risk factors for esophageal strictures after caustic ingestion at admission. From February 2015 to March 2021, all consecutive patients with esophageal or gastric caustic injury score ≥ II according to the Zargar classification were retrospectively analyzed. For each patient, we collected over 50 criteria at admission to the emergency room and then selected among them 20 criteria with the best clinical relevance and limited missing data for risk factor analyses. Among the 184 patients included in this study, 37 developed esophageal strictures (cumulative rate 29.4%). All esophageal strictures occurred within 3 months. In multivariate analyses, the risk factors for esophageal strictures were voluntary ingestion (cause-specific hazard ratio 5.92; 95% confidence interval 1.76–19.95, P = 0.004), Zargar’s esophageal score ≥ III (cause-specific hazard ratio 14.30; 95% confidence interval 6.07–33.67, P < 0.001), and severe ear, nose, and throat lesions (cause-specific hazard ratio 2.15; 95% confidence interval 1.09–4.22, P = 0.027). Intentional ingestion, severe endoscopic grade, and severe ENT lesions were identified as risk factors for esophageal stricture following caustic ingestion. Preventive measures for this population require further evaluation.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Date de dépôt :

2024-02-09T22:12:24Z
2024-03-08T11:26:38Z

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