Titre :

Characterisation of airway disease associated with Sjögren disease.

Auteur(s) :

Meudec, L. [Auteur]
Debray, M. P. [Auteur]
Beurnier, A. [Auteur]
Marques, C. [Auteur]
Juge, P. A. [Auteur]
Dhote, R. [Auteur]
Larroche, C. [Auteur]
Fauchais, A. L. [Auteur]
Dernis, E. [Auteur]
Vittecoq, O. [Auteur]
Saraux, A. [Auteur]
Gottenberg, J. E. [Auteur]
Hachulla, Eric [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Le Guern, V. [Auteur]
Dieudé, P. [Auteur]
Seror, R. [Auteur]
Mariette, X. [Auteur]
Nocturne, G. [Auteur]

Titre de la revue :

RMD Open : Rheumatic & Musculoskeletal Diseases

Nom court de la revue :

RMD Open

Numéro :

10

Pagination :

e003866

Éditeur :

BMJ Journals

Date de publication :

2024-03-03

ISSN :

2056-5933

Mot(s)-clé(s) en anglais :

Sjogren's Syndrome
Epidemiology
Risk Factors
Autoimmune Diseases

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Objective Although airway disease associated with Sjögren’s disease (Sjo-AD) is common, it is poorly studied compared with interstitial lung disease (ILD). In this study, we aimed to assess factors associated with Sjo-AD, ...
Lire la suite >Objective Although airway disease associated with Sjögren’s disease (Sjo-AD) is common, it is poorly studied compared with interstitial lung disease (ILD). In this study, we aimed to assess factors associated with Sjo-AD, the characteristics and prognosis of this manifestation. Methods We performed a retrospective multicentric study involving nine centres. We included Sjo-AD patients confirmed by at least one clinician and one CT scan report. Clinical and biological data, pulmonary function test (PFT), and CT scans were collected. A single radiologist specialist in thoracic diseases reviewed CT scans. Sjo-AD patients were compared with Sjo controls without pulmonary involvement, randomly selected after matching for age and disease duration. Results We included 31 Sjo-AD and 62 Sjo controls without pulmonary history. Sjo-AD had a higher disease activity (ESSDAI) compared with controls, even when excluding the pulmonary domain of the score (7 vs 3.8, p<0.05), mainly due to the biological activity. Sjo-AD was multilobar (72%) and associated with signs of both bronchiectasis and bronchiolitis (60%). Obstructive lung disease occurred in 32% at the time of Sjo-AD diagnosis. Overall, PFT was stable after 8.7±7 years follow-up but repeated CT scans showed extended lesions in 41% of cases within 6±3.2 years. No patient developed Sjo-ILD. Sjo-AD progression was independent of the global disease activity. Conclusions Sjo-AD preferentially affects Sjo patients with higher biological activity. It is often characterised as a diffuse disease, affecting both proximal and distal airways, with a slow evolution over time and no progression to Sjo-ILD.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Date de dépôt :

2024-05-06T21:43:18Z
2024-09-04T07:53:26Z