Omega-3 polyunsaturated fatty acids improve ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Omega-3 polyunsaturated fatty acids improve host response in chronic Pseudomonas aeruginosa lung infection in mice.
Auteur(s) :
Pierre, Maud [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Le Berre, Rozenn [Auteur]
Faculté de Médecine Henri Warembourg - Université de Lille
Desseyn, Jean-Luc [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Galabert, Claude [Auteur]
Hôpital Renée Sabran [CHU - HCL]
Beghin, Laurent [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Beermann, Christopher [Auteur]
University of Applied Sciences [Fulda]
Dagenais, André [Auteur]
Centre Hospitalier de l'Université de Montréal [CHUM]
Berthiaume, Yves [Auteur]
Centre Hospitalier de l'Université de Montréal [CHUM]
cardinaud, bruno [Auteur]
Université Nice Sophia Antipolis (1965 - 2019) [UNS]
barbry, pascal [Auteur]
Université Nice Sophia Antipolis (1965 - 2019) [UNS]
gottrand, frederic [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
guery, benoit [Auteur]
Faculté de Médecine Henri Warembourg - Université de Lille
cardinaud, bruno [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Le Berre, Rozenn [Auteur]
Faculté de Médecine Henri Warembourg - Université de Lille
Desseyn, Jean-Luc [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Galabert, Claude [Auteur]
Hôpital Renée Sabran [CHU - HCL]
Beghin, Laurent [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Beermann, Christopher [Auteur]
University of Applied Sciences [Fulda]
Dagenais, André [Auteur]
Centre Hospitalier de l'Université de Montréal [CHUM]
Berthiaume, Yves [Auteur]
Centre Hospitalier de l'Université de Montréal [CHUM]
cardinaud, bruno [Auteur]
Université Nice Sophia Antipolis (1965 - 2019) [UNS]
barbry, pascal [Auteur]
Université Nice Sophia Antipolis (1965 - 2019) [UNS]
gottrand, frederic [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
guery, benoit [Auteur]
Faculté de Médecine Henri Warembourg - Université de Lille
cardinaud, bruno [Auteur]
Titre de la revue :
American journal of physiology. Lung cellular and molecular physiology
Nom court de la revue :
Am J Physiol Lung Cell Mol Physiol
Numéro :
292
Pagination :
L1422-31
Date de publication :
2007-06-01
ISSN :
1040-0605
Mot(s)-clé(s) en anglais :
Animal Feed
Animals
Bronchoalveolar Lavage Fluid
Epithelial Sodium Channels
Extravascular Lung Water
Fatty Acids
Omega-3
Interleukin-6
Male
Mice
Mice
Inbred C57BL
Neutrophils
Pneumonia
Bacterial
Pseudomonas Infections
Pseudomonas aeruginosa
Pulmonary Alveoli
RNA
Messenger
Sodium-Potassium-Exchanging ATPase
Tumor Necrosis Factor-alpha
Weight Loss
Animals
Bronchoalveolar Lavage Fluid
Epithelial Sodium Channels
Extravascular Lung Water
Fatty Acids
Omega-3
Interleukin-6
Male
Mice
Mice
Inbred C57BL
Neutrophils
Pneumonia
Bacterial
Pseudomonas Infections
Pseudomonas aeruginosa
Pulmonary Alveoli
RNA
Messenger
Sodium-Potassium-Exchanging ATPase
Tumor Necrosis Factor-alpha
Weight Loss
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Pseudomonas aeruginosa is a gram-negative bacilli frequently encountered in human pathology. This pathogen is involved in a large number of nosocomial infections and chronic diseases. Herein we investigated the effects of ...
Lire la suite >Pseudomonas aeruginosa is a gram-negative bacilli frequently encountered in human pathology. This pathogen is involved in a large number of nosocomial infections and chronic diseases. Herein we investigated the effects of polyunsaturated fatty acids (PUFA) in chronic Pseudomonas aeruginosa lung infection. C57BL/6 mice were fed for 5 wk with specifically designed diets with high contents in either omega-3 (omega-3) or omega-6 PUFA and compared to a control diet. P. aeruginosa included in agarose beads was then instilled intratracheally, and the animals were studied for 7 days. On the 4th day, the mice fed with the omega-3 diet had a higher lean body mass gain and a lower omega-6:omega-3 ratio of fatty acids extracted from the lung tissue compared with the other groups (P < 0.05). The omega-3 group had the lowest mortality. Distal alveolar fluid clearance (DAFC) as well as the inflammatory response and the cellular recruitment were higher in the omega-3 group on the 4th day. The effect on DAFC was independent of alpha-epithelial Na(+) channels (alpha-ENaC), beta-ENaC, and alpha(1)-Na-K-ATPase mRNA expressions, which were not altered by the different diets. In conclusion, a diet enriched in omega-3 PUFA can change lung membrane composition and improve survival in chronic pneumonia. This effect on survival is probably multifactorial involving the increased DAFC capacity as well as the optimization of the initial inflammatory response. This work suggests that a better control of the omega-6/omega-3 PUFA balance may represent an interesting target in the prevention and/or control of P. aeruginosa infection in patients.Lire moins >
Lire la suite >Pseudomonas aeruginosa is a gram-negative bacilli frequently encountered in human pathology. This pathogen is involved in a large number of nosocomial infections and chronic diseases. Herein we investigated the effects of polyunsaturated fatty acids (PUFA) in chronic Pseudomonas aeruginosa lung infection. C57BL/6 mice were fed for 5 wk with specifically designed diets with high contents in either omega-3 (omega-3) or omega-6 PUFA and compared to a control diet. P. aeruginosa included in agarose beads was then instilled intratracheally, and the animals were studied for 7 days. On the 4th day, the mice fed with the omega-3 diet had a higher lean body mass gain and a lower omega-6:omega-3 ratio of fatty acids extracted from the lung tissue compared with the other groups (P < 0.05). The omega-3 group had the lowest mortality. Distal alveolar fluid clearance (DAFC) as well as the inflammatory response and the cellular recruitment were higher in the omega-3 group on the 4th day. The effect on DAFC was independent of alpha-epithelial Na(+) channels (alpha-ENaC), beta-ENaC, and alpha(1)-Na-K-ATPase mRNA expressions, which were not altered by the different diets. In conclusion, a diet enriched in omega-3 PUFA can change lung membrane composition and improve survival in chronic pneumonia. This effect on survival is probably multifactorial involving the increased DAFC capacity as well as the optimization of the initial inflammatory response. This work suggests that a better control of the omega-6/omega-3 PUFA balance may represent an interesting target in the prevention and/or control of P. aeruginosa infection in patients.Lire moins >
Langue :
Anglais
Audience :
Non spécifiée
Date de dépôt :
2019-07-09T14:03:11Z
2019-07-10T09:26:02Z
2021-05-28T07:55:37Z
2021-11-10T09:54:43Z
2019-07-10T09:26:02Z
2021-05-28T07:55:37Z
2021-11-10T09:54:43Z
Fichiers
- AJPlung Pierre 2007.pdf
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