Titre :

Salience network resting state functional connectivity during airway inflammation in asthma: A feature of mental health resilience?

Auteur(s) :

Laubacher, C. [Auteur]
Imhoff-Smith, T. P. [Auteur]
Klaus, D. R. [Auteur]
Frye, C. J. [Auteur]
Esnault, Stéphane [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Busse, W. W. [Auteur]
Rosenkranz, Melissa A. [Auteur]
University of Wisconsin-Madison

Titre de la revue :

Brain, Behavior, and Immunity

Nom court de la revue :

Brain Behav Immun

Numéro :

122

Pagination :

9-17

Éditeur :

Elsevier

Date de publication :

2024-08-18

ISSN :

1090-2139

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background Inflammation is an established contributor to the pathophysiology of depression and the prevalence of depression in those with chronic inflammatory disease is two- to four-fold higher than the general population. ...
Lire la suite >Background Inflammation is an established contributor to the pathophysiology of depression and the prevalence of depression in those with chronic inflammatory disease is two- to four-fold higher than the general population. Yet little is known about the neurobiological changes that confer depression or resilience to depression, that occur when episodes of heightened inflammation are frequent or span many years. Methods We used an innovative combination of longitudinal resting state functional magnetic resonance imaging coupled to segmental bronchial provocation with allergen (SBP-Ag) to assess changes in resting state functional connectivity (rsFC) of the salience network (SN) caused by an acute inflammatory exacerbation in twenty-six adults (15 female) with asthma and varying levels of depressive symptoms. Eosinophils measured in bronchoalveolar lavage fluid and blood provided an index of allergic inflammation and the Beck Depression Inventory provided an index of depressive symptoms. Results We found that in those with the highest symptoms of depression at baseline, SN rsFC declined most from pre- to post-SBP-Ag in the context of a robust eosinophilic response to challenge, but in those with low depressive symptoms SN rsFC was maintained or increased, even in those with the most pronounced SBP-Ag response. Conclusions Thus, the maintenance of SN rsFC during inflammation may be a biomarker of resilience to depression, perhaps via more effective orchestration of large-scale brain network dynamics by the SN. These findings advance our understanding of the functional role of the SN during inflammation and inform treatment recommendations for those with comorbid inflammatory disease and depression.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Date de dépôt :

2024-09-21T21:00:57Z
2024-10-02T06:14:52Z