Titre :

Alcohol Rehabilitation Within 3 Months after Alcohol Hepatitis and Survival - A National Analysis.

Auteur(s) :

Parlati, L. [Auteur]
Mouliade, C. [Auteur]
Nguyen Khac, E. [Auteur]
Collier, M. [Auteur]
Tzedakis, S. [Auteur]
Bouam, S. [Auteur]
Courtois, A. [Auteur]
Corouge, M. [Auteur]
Louvet, Alexandre [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Pol, S. [Auteur]
Sogni, P. [Auteur]
Benyamina, A. [Auteur]
Rehm, J. [Auteur]
Mathurin, Philippe [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Mallet, Vincent [Auteur]
Hôpital Cochin [AP-HP]

Titre de la revue :

Clinical Gastroenterology and Hepatology

Nom court de la revue :

Clin Gastroenterol Hepatol

Éditeur :

AGA Institute

Date de publication :

2024-09-04

ISSN :

1542-7714

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background & Aims There is limited understanding of the benefits of alcohol rehabilitation after alcohol hepatitis (AH). Methods We conducted a 2012 to 2021 national longitudinal study involving adult inpatients diagnosed ...
Lire la suite >Background & Aims There is limited understanding of the benefits of alcohol rehabilitation after alcohol hepatitis (AH). Methods We conducted a 2012 to 2021 national longitudinal study involving adult inpatients diagnosed with AH in France. We assessed the primary outcome of liver transplantation or death within 1 year after AH, including in its complicated form (CAH) defined as ≥2 hepatic or extrahepatic complications within 4 weeks after AH. The primary exposure was in-hospital alcohol rehabilitation within 3 months following AH. Patients who died (6.5%; n = 5282) or were censored (12.5%; n = 10,180) ≤4 weeks after AH were excluded. We measured adjusted hazard ratios (aHRs) and adjusted odds ratios (aORs) within the full cohort and propensity-matched samples. Results Among 65,737 patients (median age, 52 years; interquartile range [IQR], 44–60 years; 76% male), 12% died or underwent liver transplantation. In-hospital alcohol rehabilitation was noted for 25% of patients (15.2% among patients with CAH) and was the primary discharge diagnosis for 13.3%. The 1-year transplant-free survival rates were 94% (95% confidence interval [CI], 94%–95%) for rehabilitated patients, compared with 85% (95% CI, 85%–86%) for those without (aHR, 0.62; 95% CI, 0.57–0.69; P < .001). Among patients with CAH, transplant-free survival was 78% (95% CI, 76%–81%) with rehabilitation vs 70% (95% CI, 69%–71%) without (aHR, 0.82; 95% CI, 0.68–0.98; P = .025). In propensity-matched samples, rehabilitation was linked to an aOR of 0.54 (95% CI, 0.49–0.55; P < .001) overall, and 0.73 (95% CI, 0.60–0.89; P = .002) among matched patients with CAH. Conclusions In-hospital alcohol rehabilitation within 3 months after AH and CAH improve transplant-free survival rate but remain underutilized.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Date de dépôt :

2025-01-01T22:05:19Z
2025-01-15T09:06:25Z