Titre :

Long-term outcome of oesophageal atresia in adolescence (TransEAsome): a national French cohort study protocol

Auteur(s) :

Leroy, Mélanie [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Aumar, Madeleine [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Duhamel, Marie [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Dauchet, Luc [Auteur]
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Figeac, Martin [Auteur]
Plateformes Lilloises en Biologie et Santé (PLBS) - UAR 2014 - US 41
Gaillard, Segolene [Auteur]
Hospices Civils de Lyon [HCL]
Hankard, Regis [Auteur]
Université de Tours [UT]
Labreuche, Julien [Auteur]
Service de Biostatistiques [CHRU Lille]
Marot, Guillemette [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Reversat, Julie [Auteur]
Armand, Viviane [Auteur]
Salzet, Michel [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Sfeir, Rony [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Vandel, Jimmy [Auteur]
Plateforme de bioinformatique et de biostatistique de Lille - PLBS [Bilille]
Gottrand, Frédéric [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]

Titre de la revue :

BMJ Open

Nom court de la revue :

BMJ Open

Numéro :

15

Pagination :

e086303

Éditeur :

BMJ

Date de publication :

2025-01-11

ISSN :

2044-6055

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Introduction The TransEAsome project, funded by the Agence Nationale de la Recherche, aims to evaluate the long-term outcomes of patients with oesophageal atresia (OA) between 13 and 14 years old and establish multiomics ...
Lire la suite >Introduction The TransEAsome project, funded by the Agence Nationale de la Recherche, aims to evaluate the long-term outcomes of patients with oesophageal atresia (OA) between 13 and 14 years old and establish multiomics profiles using data from the world’s biggest OA registry. Methods and analysis TransEAsome is a national multicentre population-based cohort study recruiting participants from all qualified French centres for OA surgery at birth. The primary objective is to assess the prevalence of gastro-oesophageal reflux disease in adolescence among patients with OA, with several secondary objectives including the identification of risk factors and multiomic profiles from oesophageal biopsies and blood samples collected between 13 and 14 years old, compared with a control group. This comprehensive characterisation of phenotype and omic profiles aims to enhance the understanding of disease evolution in patients with OA and inform tailored care management strategies. Ethics and dissemination The study, coconstructed with input from patients, parents and research-expert adolescents, has obtained approval from the ethics research committee: Comité de protection des personnes Est II. Findings will be disseminated to various target audiences, including the scientific community, research participants, the patient community, the general public, regulatory authorities and policymakers. Data will be made available in a Findable, Accessible, Interoperable, Reusable format on the France Cohortes platform on study completion.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Date de dépôt :

2025-01-13T09:54:09Z
2025-01-15T09:38:34Z