Titre :

Endothelium structure and function in kidney health and disease.

Auteur(s) :

Jourde-Chiche, Noemie [Auteur]
Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research [C2VN]
Fakhouri, Fadi [Auteur]
Centre de Recherche en Transplantation et Immunologie [U1064 Inserm - CRTI]
Dou, Laetitia [Auteur]
Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research [C2VN]
Bellien, Jeremy [Auteur]
Université de Rouen Normandie [UNIROUEN]
Burtey, Stephane [Auteur]
Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research [C2VN]
Frimat, Marie [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Jarrot, Pierre-Andre [Auteur]
Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research [C2VN]
Kaplanski, Gilles [Auteur]
Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research [C2VN]
Le Quintrec, Moglie [Auteur]
Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB)
Pernin, Vincent [Auteur]
Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB)
Rigothier, Claire [Auteur]
Université de Bordeaux [UB]
Sallee, Marion [Auteur]
Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research [C2VN]
Fremeaux-Bacchi, Veronique [Auteur]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Guerrot, Dominique [Auteur]
Université de Rouen Normandie [UNIROUEN]
Roumenina, Lubka T. [Auteur]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]

Titre de la revue :

Nature Reviews Nephrology

Nom court de la revue :

Nat Rev Nephrol

Numéro :

15

Pagination :

87–108

Date de publication :

2019-02

ISSN :

1759-507X

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

The kidney harbours different types of endothelia, each with specific structural and functional characteristics. The glomerular endothelium, which is highly fenestrated and covered by a rich glycocalyx, participates in the ...
Lire la suite >The kidney harbours different types of endothelia, each with specific structural and functional characteristics. The glomerular endothelium, which is highly fenestrated and covered by a rich glycocalyx, participates in the sieving properties of the glomerular filtration barrier and in the maintenance of podocyte structure. The microvascular endothelium in peritubular capillaries, which is also fenestrated, transports reabsorbed components and participates in epithelial cell function. The endothelium of large and small vessels supports the renal vasculature. These renal endothelia are protected by regulators of thrombosis, inflammation and complement, but endothelial injury (for example, induced by toxins, antibodies, immune cells or inflammatory cytokines) or defects in factors that provide endothelial protection (for example, regulators of complement or angiogenesis) can lead to acute or chronic renal injury. Moreover, renal endothelial cells can transition towards a mesenchymal phenotype, favouring renal fibrosis and the development of chronic kidney disease. Thus, the renal endothelium is both a target and a driver of kidney and systemic cardiovascular complications. Emerging therapeutic strategies that target the renal endothelium may lead to improved outcomes for both rare and common renal diseases.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Date de dépôt :

2019-10-22T07:44:09Z
2023-12-21T10:49:12Z