Titre :

Association between acute graft pyelonephritis and kidney graft survival: a single-center observational study

Auteur(s) :

Maanaoui, Mehdi [Auteur]
Baes, Dulciane [Auteur]
Hamroun, Aghiles [Auteur]
Khedjat, Kahina [Auteur]
Vuotto, Fanny [Auteur]
Faure, Emmanuel [Auteur]
Lopez, Benjamin [Auteur]
Bouye, Sebastien [Auteur]
Caes, Thomas [Auteur]
Lionet, Arnaud [Auteur]
Lebas, Celine [Auteur]
Provot, Francois [Auteur]
Glowacki, Francois [Auteur]
Gibier, Jean-Baptiste [Auteur]
Lenain, Remi [Auteur]
Hazzan, Marc [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Titre de la revue :

American journal of transplantation . official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Nom court de la revue :

Am J Transplant

Date de publication :

2021-05-31

ISSN :

1600-6143

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

The association between acute graft pyelonephritis (AGPN) and graft failure in kidney transplant recipients (KTR) remains controversial. In this single-center observational study, we aimed to assess the incidence of AGPN ...
Lire la suite >The association between acute graft pyelonephritis (AGPN) and graft failure in kidney transplant recipients (KTR) remains controversial. In this single-center observational study, we aimed to assess the incidence of AGPN as a time-dependent posttransplantation event. We also examined the association between the diagnosis of AGPN and graft outcomes. In total, we evaluated 1480 patients who underwent kidney transplantation between January 2007 and December 2017. During a median follow-up of 5.04 years, we observed 297 AGPN episodes that occurred in 158 KTR. To evaluate the association between AGPN and clinical outcomes, we performed Cox proportional hazards regression analyses in which AGPN was entered as a time-dependent covariate. AGPN was independently associated with an increased risk of graft loss (hazard ratio = 1.66; 95% confidence interval [CI]: 1.05-2.64, p < .03) and a persistently decreased eGFR (fixed effect on intercept: -2.29 ml/min/1.73 m2Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Date de dépôt :

2021-07-06T12:44:14Z