Titre :

Validation and update of the Lémann index to measure cumulative structural bowel damage in Crohn's disease

Auteur(s) :

Pariente, Benjamin [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Torres, Joana [Auteur]
Burisch, Johan [Auteur]
Hvidovre Hospital
Arebi, Naila [Auteur]
Imperial College London
Barberio, Brigida [Auteur]

Duricova, Dana [Auteur]
Univerzita Karlova [Praha, Česká republika] = Charles University [Prague, Czech Republic] [UK]
Ellul, Pierre [Auteur]
Mater Dei Hospital [Malta]
Goldis, Adrian [Auteur]
Universitatea Tibiscus din Timişoara [România] = Tibiscus University of Timisoara [Romania] = Université Tibiscus de Timişoara [Roumanie]
Kaimakliotis, Ioannis P. [Auteur]
Katsanos, Konstantinos H. [Auteur]
University Hospital of Ioannina
Krznaric, Zeljko [Auteur]
University Hospital Centre Zagreb
Namara, Deirdre Mc [Auteur]
Trinity College Dublin
Pedersen, Natalia [Auteur]
Sebastian, Shaji [Auteur]
University of Hull [United Kingdom]
Azahaf, Mustapha [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Weimers, Petra [Auteur]
Lung, Philip [Auteur]
Imperial College London
Lacognata, Carmelo [Auteur]
Università degli Studi di Padova = University of Padua [Unipd]
Horak, Martin [Auteur]
Czech Technical University in Prague [CTU]
Christodoulou, Dimitrios K. [Auteur]
University Hospital of Ioannina
Domislovic, Viktor [Auteur]
University Hospital Centre Zagreb
Murphy, Ian [Auteur]
Lambert, Jerome [Auteur]
Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques [CRESS (U1153 / UMR_A 1125)]
Ungaro, Ryan C. [Auteur]
Icahn School of Medicine at Mount Sinai [New York] [MSSM]
Colombel, Jean-Frédéric [Auteur]
Icahn School of Medicine at Mount Sinai [New York] [MSSM]
Mary, Jean-Yves [Auteur]
Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques [CRESS (U1153 / UMR_A 1125)]

Titre de la revue :

Gastroenterology

Nom court de la revue :

Gastroenterology

Date de publication :

2021-05-27

ISSN :

1528-0012

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

BACKGROUND: The Lémann index is a tool measuring cumulative structural bowel damage in Crohn's disease (CD). We here report its validation and updating. METHODS: This was an international, multicenter, prospective, ...
Lire la suite >BACKGROUND: The Lémann index is a tool measuring cumulative structural bowel damage in Crohn's disease (CD). We here report its validation and updating. METHODS: This was an international, multicenter, prospective, cross-sectional observational study. At each center, 10 inclusions, stratified by CD duration and location, were planned. For each patient, the digestive tract was divided into 4 organs, upper tract, small bowel, colon/rectum, anus, and subsequently into segments, explored systematically by magnetic resonance imaging (MRI), and by endoscopies in relation to disease location. For each segment, investigators retrieved information on previous surgical procedures, identified predefined strictures and penetrating lesions of maximal severity (grades 1-3) at each organ investigational method (gastroenterologist and radiologist for MRI), provided segmental damage evaluation ranging from 0.0 to 10.0 (complete resection). Organ resection-free cumulative damage evaluation was then calculated from the sum of segmental damages. Then, investigators provided a 0-10 global damage evaluation from the 4 organ standardized cumulative damage evaluations. Simple linear regressions of investigator damage evaluations on their corresponding Lémann index were studied, as well as calibration plots. Finally, updated Lémann index was derived through multiple linear mixed models applied to combined development and validation samples. RESULTS: In 15 centers, 134 patients were included. Correlation coefficients between investigator damage evaluations and Lémann indexes were above 0.80. When analyzing data in 272 patients from both samples and 27 centers, the unbiased correlation estimates were 0.89, 0,97, 0,94, 0.81, 0.91 for the 4 organs and globally, and stable when applied to one sample or the other. CONCLUSIONS: The updated Lémann index is a well-established index to assess cumulative bowel damage in Crohn's disease that can be used in epidemiological studies and disease modification trials.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Date de dépôt :

2021-07-06T12:44:15Z
2024-01-31T10:55:15Z