Title :

Clinical significance of anti-ro52 (trim21) antibodies in adult patients with connective tissue diseases

Author(s) :

Decker, Paul [Auteur]
Centre régional de compétence des Maladies systémiques et auto-immunes rares de l'adulte et Maladies vasculaires rares
Centre Hospitalier Universitaire de Nancy [CHU Nancy]
Moulinet, Thomas [Auteur]
Centre Hospitalier Régional Universitaire de Nancy [CHRU Nancy]
Centre régional de compétence des Maladies systémiques et auto-immunes rares de l'adulte et Maladies vasculaires rares
Lopez, Benjamin [Auteur]
Institut d'Immunologie [CHRU Lille]
Dubucquoi, Sylvain [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Bonnotte, Bernard [Auteur]
Service de médecine interne et immunologie clinique (SOC 1) [CHU de Dijon]
Centre de référence des maladies rares des cytopénies auto-immunes de l'adulte (CHU Dijon) [CRMR des cytopénies auto-immunes de l'adulte ]
CHU Dijon
Lakomy, Daniela [Auteur]
CHU Dijon
Revuz, Sabine [Auteur]
Hôpital-Clinique Claude-Bernard [Metz]
Luc, Amandine [Auteur]
Centre Hospitalier Régional Universitaire de Nancy [CHRU Nancy]
Département Méthodologie Promotion Investigation [CHRU Nancy] [MPI]
Bittencourt, Marcelo De Carvalho [Auteur]
Centre Hospitalier Régional Universitaire de Nancy [CHRU Nancy]
Ingénierie Moléculaire et Physiopathologie Articulaire [IMoPA]
Hachulla, Eric [Auteur]
Centre de référence des maladies auto-immunes systémiques rares du Nord et Nord Ouest [CHRU Lille]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Jaussaud, Roland [Auteur]
Centre Hospitalier Régional Universitaire de Nancy [CHRU Nancy]
Centre régional de compétence des Maladies systémiques et auto-immunes rares de l'adulte et Maladies vasculaires rares

Journal title :

European Journal of Internal Medicine

Abbreviated title :

Eur J Intern Med

Publication date :

2021-05-07

ISSN :

1879-0828

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVE: Clinical significance of anti-Ro52 antibodies in connective tissue diseases (CTD) is controversial. Anti-Ro52 antibodies might be associated with a more severe CTD phenotype, especially interstitial lung disease ...
Show more >OBJECTIVE: Clinical significance of anti-Ro52 antibodies in connective tissue diseases (CTD) is controversial. Anti-Ro52 antibodies might be associated with a more severe CTD phenotype, especially interstitial lung disease (ILD). The aims of this study were to evaluate ILD prevalence and severity, the prevalence of micro- or macroangiopathy and CTD-associated cancers in CTD with anti-Ro52 antibodies. METHODS: CTD patients with anti-Ro52 antibody screening by immunoblot at diagnosis were enrolled. Two groups were retrospectively formed according to the presence of anti-Ro52 antibodies with an unbiased 1:1 matching on CTD types. Unsupervised multiple correspondence analysis and hierarchical clustering analysis were used to aggregate anti-Ro52 positive patients in subgroups. RESULTS: 408 CTD patients were included. Anti-Ro52 antibodies were detected in 33 % of CTD patients. Anti-Ro52 antibodies were associated with ILD at CTD diagnosis (47.8% vs. 23.0%, OR 3.3 95% IC 1.4 to 8.0, p = 0.008), even after adjusting for the presence of anti-Ro60 antibodies, especially in patients with antisynthetase syndrome, primary Sjögren syndrome and systemic sclerosis. Micro- or macroangiopathy was more frequent in anti-Ro52 positive CTD patients (18.6% vs. 9.7%, p = 0.02) and CTD patients with anti-Ro52 antibodies experienced more frequent relapses and required more immunosuppressive drugs. Clusters 4 and 5 identified anti-Ro52 positive CTD patients with severe ILD and with clinical features of systemic sclerosis or antisynthetase syndrome respectively. CONCLUSIONS: We found that anti-Ro52 antibodies were independently associated with ILD in CTD patients irrespective of CTD type. Anti-Ro52 antibodies could be associated with severity and a more relapsing disease course in CTD patients.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2021-07-06T12:44:21Z
2024-03-05T10:00:18Z