Epidemiology of cutaneous involvement in ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Epidemiology of cutaneous involvement in sjögren syndrome: data from three french pss populations (tears, assess, diapss)
Auteur(s) :
Villon, Camille [Auteur]
Orgeolet, Laure [Auteur]
Roguedas, Anne-Marie [Auteur]
Misery, Laurent [Auteur]
Gottenberg, Jacques-Eric [Auteur]
Cornec, Divi [Auteur]
Jousse-Joulin, Sandrine [Auteur]
Seror, Raphaele [Auteur]
Berthelot, Jean-Marie [Auteur]
Dieude, Philippe [Auteur]
Dubost, Jean-Jacques [Auteur]
Fauchais, Anne-Laure [Auteur]
Goeb, Vincent [Auteur]
Hachulla, Eric [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Hatron, Pierre-Yves [Auteur]
Larroche, Claire [Auteur]
Hayem, Gilles [Auteur]
Le Guern, Véronique [Auteur]
Perdriger, Aleth [Auteur]
Morel, Jacques [Auteur]
Vittecoq, Olivier [Auteur]
Mariette, Xavier [Auteur]
Devauchelle-Pensec, Valerie [Auteur]
Saraux, Alain [Auteur]
Orgeolet, Laure [Auteur]
Roguedas, Anne-Marie [Auteur]
Misery, Laurent [Auteur]
Gottenberg, Jacques-Eric [Auteur]
Cornec, Divi [Auteur]
Jousse-Joulin, Sandrine [Auteur]
Seror, Raphaele [Auteur]
Berthelot, Jean-Marie [Auteur]
Dieude, Philippe [Auteur]
Dubost, Jean-Jacques [Auteur]
Fauchais, Anne-Laure [Auteur]
Goeb, Vincent [Auteur]
Hachulla, Eric [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Hatron, Pierre-Yves [Auteur]
Larroche, Claire [Auteur]
Hayem, Gilles [Auteur]
Le Guern, Véronique [Auteur]
Perdriger, Aleth [Auteur]
Morel, Jacques [Auteur]
Vittecoq, Olivier [Auteur]
Mariette, Xavier [Auteur]
Devauchelle-Pensec, Valerie [Auteur]
Saraux, Alain [Auteur]
Titre de la revue :
Joint, bone, spine . revue du rhumatisme
Nom court de la revue :
Joint Bone Spine
Pagination :
105162
Date de publication :
2021-02-19
ISSN :
1778-7254
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
OBJECTIVE: To determine the prevalence and significance of dermatological disorders in primary Sjögren syndrome (pSS).
METHODS: We used 2 pSS French cohorts (ASSESS, in which prevalence of skin disorders in 395 patients ...
Lire la suite >OBJECTIVE: To determine the prevalence and significance of dermatological disorders in primary Sjögren syndrome (pSS). METHODS: We used 2 pSS French cohorts (ASSESS, in which prevalence of skin disorders in 395 patients was evaluated; and diapSS, in which 76 on 139 pSS patients had an examination by a dermatologist) and baseline data of the TEARS randomized trial (110 patients with recent or active pSS treated with rituximab or placebo and evaluated for skin dryness using a visual analogue scale (VAS) out of 100). RESULTS: Skin manifestations included in the EULAR Sjögren syndrome disease activity index (ESSDAI) were rare in the ASSESS cohort (n=16/395, 4.1%, mainly purpuras; only 3 had high activity), but they were associated with activity in the other ESSDAI domains (peripheral neurological (P<0.001), muscular (P<0.01), haematological (P<0.05), biological (P<0.05), history of arthritis (P<0.01), splenomegaly (P<0.05) and higher gamma globulin levels (P<0.01)). In the diapSS cohort, compared to pSS patients not receiving a dermatological consultation, the pSS patients who had a dermatological consultation had significantly more dermatological involvement outside the ESSDAI score [38.2% (29/76) versus 15.9% (10/63); P<0.01]. The TEARS study showed a high prevalence of cutaneous dryness (VAS>50; 48.2%) and found that patients with dry skin had higher VAS pain (P<0.01) and drought (P<0.01) scores. CONCLUSIONS: ESSDAI skin activity is rare and associated with hypergammaglobulinemia and ESSDAI activity. Systematic dermatological examination is informative for non-specific lesions. The most common skin disorder is skin dryness, which is associated with a higher pain and overall subjective dryness.Lire moins >
Lire la suite >OBJECTIVE: To determine the prevalence and significance of dermatological disorders in primary Sjögren syndrome (pSS). METHODS: We used 2 pSS French cohorts (ASSESS, in which prevalence of skin disorders in 395 patients was evaluated; and diapSS, in which 76 on 139 pSS patients had an examination by a dermatologist) and baseline data of the TEARS randomized trial (110 patients with recent or active pSS treated with rituximab or placebo and evaluated for skin dryness using a visual analogue scale (VAS) out of 100). RESULTS: Skin manifestations included in the EULAR Sjögren syndrome disease activity index (ESSDAI) were rare in the ASSESS cohort (n=16/395, 4.1%, mainly purpuras; only 3 had high activity), but they were associated with activity in the other ESSDAI domains (peripheral neurological (P<0.001), muscular (P<0.01), haematological (P<0.05), biological (P<0.05), history of arthritis (P<0.01), splenomegaly (P<0.05) and higher gamma globulin levels (P<0.01)). In the diapSS cohort, compared to pSS patients not receiving a dermatological consultation, the pSS patients who had a dermatological consultation had significantly more dermatological involvement outside the ESSDAI score [38.2% (29/76) versus 15.9% (10/63); P<0.01]. The TEARS study showed a high prevalence of cutaneous dryness (VAS>50; 48.2%) and found that patients with dry skin had higher VAS pain (P<0.01) and drought (P<0.01) scores. CONCLUSIONS: ESSDAI skin activity is rare and associated with hypergammaglobulinemia and ESSDAI activity. Systematic dermatological examination is informative for non-specific lesions. The most common skin disorder is skin dryness, which is associated with a higher pain and overall subjective dryness.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Date de dépôt :
2021-07-06T12:44:40Z