Titre :

Alcohol consumption the day of liver transplantation for alcohol-associated liver disease does not affect long-term survival: a case-control study

Auteur(s) :

Ursic-Bedoya, Jose [Auteur]
Dumortier, Jerome [Auteur]
Altwegg, Romain [Auteur]
Belkacemi, Mohamed [Auteur]
Vanlemmens, Claire [Auteur]
Dharancy, Sebastien [Auteur]
Besch, Camille [Auteur]
Shili-Masmoudi, Sarah [Auteur]
Francoz, Claire [Auteur]
Boillot, Olivier [Auteur]
Meszaros, Magdalena [Auteur]
Meunier, Lucy [Auteur]
Faure, Stephanie [Auteur]
Herrero, Astrid [Auteur]
Donnadieu-Rigole, Helene [Auteur]
Pageaux, Georges-Philippe [Auteur]

Titre de la revue :

Liver transplantation . official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

Nom court de la revue :

Liver Transpl.

Date de publication :

2020-09-25

ISSN :

1527-6473

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Alcohol abstinence before liver transplantation (LT) for alcohol-associated liver disease (ALD) is required for every candidate. Some listed patients might relapse, resulting in LT for patients nonabstinent during the ...
Lire la suite >Alcohol abstinence before liver transplantation (LT) for alcohol-associated liver disease (ALD) is required for every candidate. Some listed patients might relapse, resulting in LT for patients nonabstinent during the pretransplant period. Long-term survival outcomes of these patients have never been studied. We sought to determine whether alcohol consumption on the day of the LT influenced long-term survival after LT. We conducted a retrospective case-control study among French LT centers. Cases were defined as recipients between January 1995 and December 2007 having positive blood and/or urine alcohol levels the day of LT. Each case was paired with 2 controls corresponding to patients transplanted for ALD during the same trimester. Patients were classified into 3 categories per alcohol consumption: abstainers, occasional or transitory excessive consumers, or patients with a sustained excessive consumption (daily consumption >20-30 g/day). During the study period, 3052 LTs for ALD were conducted in France. We identified 42 cases paired with 84 controls. Median blood alcohol level was 0.4 g/L (range 0.1-4.1 g/L) and median urine alcohol level was 0.2 g/L (range 0.1-2.0 g/L). Median follow-up period until death or censoring was 12.9 years (CI95%95%2Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Date de dépôt :

2021-07-06T12:46:04Z