Title :

Do we need to assess quality-of-life with both the st george's respiratory questionnaire and the euroqol 5-dimension questionnaire in a clinical study with an economic component: insights from the revolens study in severe emphysema

Author(s) :

Bulsei, Julie [Auteur]
Assistance publique - Hôpitaux de Paris (AP-HP) [AP-HP]
Pfister, Jeanne [Auteur]
Assistance publique - Hôpitaux de Paris (AP-HP) [AP-HP]
Leroy, Sylvie [Auteur]
FHU OncoAge - Pathologies liées à l’âge [CHU Nice] [OncoAge]
Perotin, Jeanne Marie [Auteur]
Pathologies Pulmonaires et Plasticité Cellulaire - UMR-S 1250 [P3CELL]
Barbe, Coralie [Auteur]
Hôpital universitaire Robert Debré [Reims] [CHU Reims]
Marquette, Charles-Hugo [Auteur]
FHU OncoAge - Pathologies liées à l’âge [CHU Nice] [OncoAge]
Deslee, Gaetan [Auteur]
Pathologies Pulmonaires et Plasticité Cellulaire - UMR-S 1250 [P3CELL]
Durand-Zaleski, Isabelle [Auteur]
Assistance publique - Hôpitaux de Paris (AP-HP) [AP-HP]
Dury, Sandra [Auteur]
Vallerand, Herve [Auteur]
Lebargy, Francois [Auteur]
Launois, Claire [Auteur]
Pradelli, Johanna [Auteur]
Benzaquen, Jonathan [Auteur]
Buscot, Matthieu [Auteur]
Sanfiorenzo, Celine [Auteur]
Korzeniewski, Sylvia [Auteur]
Mazzetta, Andrea [Auteur]
Griffonnet, Jennifer [Auteur]
Guillemart, Ariane [Auteur]
Makris, Demosthenes [Auteur]
Mal, Herve [Auteur]
Dombret, Marie Christine [Auteur]
Servin, Frederique [Auteur]
Debray, Marie Pierre [Auteur]
Dutau, Herve [Auteur]
Laroumagne, Sophie [Auteur]
Bregeon, Fabienne [Auteur]
Gomez, Carine [Auteur]
Astoul, Philippe [Auteur]
Lesavre, Nathalie [Auteur]
Bourdin, Arnaud [Auteur]
Mallet, Jean Pierre [Auteur]
Gamez, Anne Sophie [Auteur]
Tarodo, Philippe [Auteur]
Brousse, Christophe [Auteur]
Broissin, Clement [Auteur]
Vergnon, Jean Michel [Auteur]
Thibout, Yoann [Auteur]
Di Palma, Fabrice [Auteur]
Costes, Frederic [Auteur]
Pison, Christophe [Auteur]
Briault, Amandine [Auteur]
Arbib, Francois [Auteur]
Reymond, Emilie [Auteur]
Ferrettti, G. [Auteur]
Kessler, Romain [Auteur]
Porzio, Michele [Auteur]
Renaud-Picard, Benjamin [Auteur]
Jounieaux, Vincent [Auteur]
Toublanc, Benedicte [Auteur]
Francois, Geraldine [Auteur]
Salaun, Mathieu [Auteur]
Thiberville, Luc [Auteur]
Cuvelier, Antoine [Auteur]
Lachkar, Samy [Auteur]
Gras, Delphine [Auteur]
Benoit, Philippe [Auteur]
Leclainche, Annick [Auteur]
Jolly, Damien [Auteur]
Fourrier, Francois [Auteur]
Hachulla, Eric [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Roche, Nicolas [Auteur]
Dusser, Daniel [Auteur]

Journal title :

International Journal of Chronic Obstructive Pulmonary Disease

Abbreviated title :

Int. J. Chronic Obstr. Pulm. Dis.

Volume number :

15

Pages :

135-142

Publication date :

2020-01-01

ISSN :

1178-2005

Keyword(s) :

concordance
correlation
EuroQol five dimensions questionnaire
St. George's Respiratory Questionnaire
quality-of-life

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The use of two quality-of-life questionnaires in a single clinical trial with an economic component can be challenging due to the associated workload in terms of data collection and an increased risk of missing data. The ...
Show more >The use of two quality-of-life questionnaires in a single clinical trial with an economic component can be challenging due to the associated workload in terms of data collection and an increased risk of missing data. The aim of our study was to determine whether the questionnaire chosen to measure health status, the St. George's Respiratory Questionnaire (SGRQ), could be administered on its own without adding the EuroQol five dimensions questionnaire (EQ-5D) for economic evaluation in emphysema studies. Data were prospectively collected during the REVOLENS trial assessing endobronchial coil treatment in severe emphysema. To quantify the association between the two questionnaires, correlations between the EQ-5D and the SGRQ were first tested and the concordance was then studied in order to know whether the two questionnaires were interchangeable. Finally, the Starkie et al algorithm predicting EQ-5D utility values from the SGRQ was used on REVOLENS's individual patient data. The Student's t Results showed a strong correlation but no concordance between the EQ-5D and the SGRQ, demonstrating that the two questionnaires are not interchangeable. Moreover, the algorithm predicting EQ-5D utilities from the SGRQ did not provide utility values comparable to those observed in the REVOLENS study. Indeed, our study demonstrated a strong correlation between predicted and individual EQ-5D values but no concordance. The use of both the EQ-5D and the SGRQ in a clinical study with an economic component is justified. Based on our results, the SGRQ should not be used to obtain a utility score to calculate the incremental cost-effectiveness ratio and conclude on the efficiency of an intervention in emphysema patients. Keywords: quality-of-life, St. George’s Respiratory Questionnaire, EuroQol five dimensions questionnaire, correlation, concordanceShow less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2021-07-06T12:46:41Z
2024-02-06T10:21:59Z