Draft for internal testing Scientific ...
Type de document :
Article dans une revue scientifique: Article original
DOI :
PMID :
URL permanente :
Titre :
Draft for internal testing Scientific Committee guidance on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments
Auteur(s) :
More, Simon [Auteur]
Bampidis, Vasileios [Auteur]
Benford, Diane [Auteur]
Bragard, Claude [Auteur]
Hernandez-Jerez, Antonio [Auteur]
Hougaard Bennekou, Susanne [Auteur]
Koutsoumanis, Kostas [Auteur]
Machera, Kyriaki [Auteur]
Naegeli, Hanspeter [Auteur]
Nielsen, Soren Saxmose [Auteur]
Schlatter, Josef Rudolf [Auteur]
Schrenk, Dieter [Auteur]
Silano, Vittorio [Auteur]
Turck, Dominique [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Younes, Maged [Auteur]
Fletcher, Tony [Auteur]
Greiner, Matthias [Auteur]
Ntzani, Evangelia [Auteur]
Pearce, Neil [Auteur]
Vinceti, Marco [Auteur]
Ciccolallo, Laura [Auteur]
Georgiadis, Marios [Auteur]
Gervelmeyer, Andrea [Auteur]
Halldorsson, Thorhallur I. [Auteur]
Bampidis, Vasileios [Auteur]
Benford, Diane [Auteur]
Bragard, Claude [Auteur]
Hernandez-Jerez, Antonio [Auteur]
Hougaard Bennekou, Susanne [Auteur]
Koutsoumanis, Kostas [Auteur]
Machera, Kyriaki [Auteur]
Naegeli, Hanspeter [Auteur]
Nielsen, Soren Saxmose [Auteur]
Schlatter, Josef Rudolf [Auteur]
Schrenk, Dieter [Auteur]
Silano, Vittorio [Auteur]
Turck, Dominique [Auteur]

Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Younes, Maged [Auteur]
Fletcher, Tony [Auteur]
Greiner, Matthias [Auteur]
Ntzani, Evangelia [Auteur]
Pearce, Neil [Auteur]
Vinceti, Marco [Auteur]
Ciccolallo, Laura [Auteur]
Georgiadis, Marios [Auteur]
Gervelmeyer, Andrea [Auteur]
Halldorsson, Thorhallur I. [Auteur]
Titre de la revue :
EFSA Journal
Nom court de la revue :
EFSA J
Numéro :
18
Pagination :
e06221
Date de publication :
2020-08
ISSN :
1831-4732
Mot(s)-clé(s) :
hazard characterisation
evidence appraisal
risk assessment
exposure assessment
Epidemiological studies
evidence appraisal
risk assessment
exposure assessment
Epidemiological studies
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
EFSA requested its Scientific Committee to prepare a guidance document on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments. The guidance document provides an ...
Lire la suite >EFSA requested its Scientific Committee to prepare a guidance document on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments. The guidance document provides an introduction to epidemiological studies and illustrates the typical biases of the different epidemiological study designs. It describes key epidemiological concepts relevant for evidence appraisal. Regarding study reliability, measures of association, exposure assessment, statistical inferences, systematic error and effect modification are explained. Regarding study relevance, the guidance describes the concept of external validity. The principles of appraising epidemiological studies are illustrated, and an overview of Risk of Bias (RoB) tools is given. A decision tree is developed to assist in the selection of the appropriate Risk of Bias tool, depending on study question, population and design. The customisation of the study appraisal process is explained, detailing the use of RoB tools and assessing the risk of bias in the body of evidence. Several examples of appraising experimental and observational studies using a Risk of Bias tool are annexed to the document to illustrate the application of the approach. This document constitutes a draft that will be applied in EFSA's assessments during a 1-year pilot phase and be revised and complemented as necessary. Before finalisation of the document, a public consultation will be launched.Lire moins >
Lire la suite >EFSA requested its Scientific Committee to prepare a guidance document on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments. The guidance document provides an introduction to epidemiological studies and illustrates the typical biases of the different epidemiological study designs. It describes key epidemiological concepts relevant for evidence appraisal. Regarding study reliability, measures of association, exposure assessment, statistical inferences, systematic error and effect modification are explained. Regarding study relevance, the guidance describes the concept of external validity. The principles of appraising epidemiological studies are illustrated, and an overview of Risk of Bias (RoB) tools is given. A decision tree is developed to assist in the selection of the appropriate Risk of Bias tool, depending on study question, population and design. The customisation of the study appraisal process is explained, detailing the use of RoB tools and assessing the risk of bias in the body of evidence. Several examples of appraising experimental and observational studies using a Risk of Bias tool are annexed to the document to illustrate the application of the approach. This document constitutes a draft that will be applied in EFSA's assessments during a 1-year pilot phase and be revised and complemented as necessary. Before finalisation of the document, a public consultation will be launched.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Date de dépôt :
2021-07-06T12:47:58Z
2024-01-11T12:31:08Z
2024-01-11T12:31:08Z
Fichiers
- EFSA Journal - 2020 - - Draft for internal testing Scientific Committee guidance on appraising and integrating evidence.pdf
- Non spécifié
- Accès libre
- Accéder au document