Title :

Impact and consequences of intensive chemotherapy on intestinal barrier and microbiota in acute myeloid leukemia: the role of mucosal strengthening

Author(s) :

Hueso, Thomas [Auteur]
Ekpe, Kenneth [Auteur]
Mayeur, Camille [Auteur]
Gatse, Anna [Auteur]
Joncquel-Chevallier Curt, Marie [Auteur]
Gricourt, Guillaume [Auteur]
Rodriguez, Christophe [Auteur]
Burdet, Charles [Auteur]
Ulmann, Guillaume [Auteur]
Neut, Christel [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Lille Inflammation Research International Center - U 995 [LIRIC]
Amini, Salah-Eddine [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lepage, Patricia [Auteur]
Raynard, Bruno [Auteur]
Willekens, Christophe [Auteur]
Micol, Jean-Baptiste [Auteur]
De Botton, Stephane [Auteur]
Yakoub-Agha, Ibrahim [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
gottrand, Fréderic [Auteur]
Desseyn, Jean-Luc [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Thomas, Muriel [Auteur]
Woerther, Paul-Louis [Auteur]
Seguy, David [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Journal title :

Gut Microbes

Abbreviated title :

Gut Microbes

Volume number :

12

Pages :

1800897

Publication date :

2020-11-09

ISSN :

1949-0984

Keyword(s) :

mucus
microbiota
Intestinal barrier
chemotherapy
acute leukemia

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Induction chemotherapy (7 + 3 regimen) remains the gold standard for patients with acute myeloid leukemia (AML) but is responsible for gut damage leading to several complications such as bloodstream infection (BSI). We ...
Show more >Induction chemotherapy (7 + 3 regimen) remains the gold standard for patients with acute myeloid leukemia (AML) but is responsible for gut damage leading to several complications such as bloodstream infection (BSI). We aimed to investigate the impact of induction chemotherapy on the intestinal barrier of patients with AML and in wild-type mice. Next, we assessed the potential benefit of strengthening the mucosal barrier in transgenic mice releasing a recombinant protein able to reinforce the mucus layer (Tg222). In patients, we observed a decrease of plasma citrulline, which is a marker of the functional enterocyte mass, of short-chain fatty acids and of fecal bacterial load, except for Escherichia coliEnterococcusE. coliEnterococcusShow less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2021-07-06T12:48:02Z