Title :

Impact of preoperative enteral nutritional support on postoperative outcome in patients with crohn's disease complicated by malnutrition. Results of a subgroup analysis of the nationwide cohort registry from the getaid chirurgie group

Author(s) :

Abdalla, Solafah [Auteur]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Maladies et hormones du système nerveux [DHNS]
Benoist, Stéphane [Auteur]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Maggiori, Leon [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Zerbib, Philippe [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Lefevre, Jérémie H. [Auteur]
CHU Saint-Antoine [AP-HP]
Denost, Quentin [Auteur]
Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
Germain, Adeline [Auteur]
Service de Chirurgie Digestive Hépatobiliaire et Endocrine [CHRU Nancy]
Cotte, Eddy [Auteur]
Centre Hospitalier Lyon Sud [CHU - HCL] [CHLS]
Beyer-Berjot, Laura [Auteur]
Hôpital Nord [CHU - APHM]
Corte, Helene [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Desfourneaux, Véronique [Auteur]
Service de Chirurgie Hépatobiliaire et Digestive [Rennes] = Hepatobiliary and Digestive Surgery [Rennes]
Rahili, Amine [Auteur]
Centre Hospitalier Universitaire de Nice [CHU Nice]
Duffas, Jean-Pierre [Auteur]
Chirurgie Générale et Digestive [Rangueil]
Pautrat, Karine [Auteur]
Service de Chirurgie d'Oncologie Digestive [CHU Lariboisière]
Denet, Christine [Auteur]
Institut Mutualiste de Montsouris [IMM]
Bridoux, Valérie [Auteur]
Service de Chirurgie Digestive [CHU Rouen]
Meurette, Guillaume [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Faucheron, Jean-Luc [Auteur]
Département de chirurgie digestive et de l'urgence
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Loriau, Jérôme [Auteur]
Centre hospitalier Saint-Joseph [Paris]
Guillon, Francoise [Auteur]
Centre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
Vicaut, Éric [Auteur]
Hôpital Lariboisière-Fernand-Widal [APHP]
Université Paris Diderot - Paris 7 [UPD7]
Panis, Yves [Auteur]
Hôpital Beaujon [AP-HP]
Brouquet, Antoine [Auteur]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Maladies et hormones du système nerveux [DHNS]

Journal title :

Colorectal Disease

Abbreviated title :

Colorectal Dis

Publication date :

2021-02-23

ISSN :

1463-1318

Keyword(s) :

malnutrition
Crohn's disease
preoperative enteral nutritional support
postoperative morbidity
inflammatory bowel diseases

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVE: Postoperative morbidity is high in patients operated on for Crohn's disease (CD) complicated by malnutrition. This study aimed to evaluate the impact of preoperative enteral nutritional support (PENS) on ...
Show more >OBJECTIVE: Postoperative morbidity is high in patients operated on for Crohn's disease (CD) complicated by malnutrition. This study aimed to evaluate the impact of preoperative enteral nutritional support (PENS) on postoperative outcome in patients with CD complicated by malnutrition included in a prospective nationwide cohort. METHODS: Malnutrition was defined as body mass index <18 kg/m2 RESULTS: Among 592 patients included, 149 were selected. In the intention-to-treat population including 20 (13.4%) patients with PENS failure after PSM, 78 'upfront surgery' and 71 'PENS'-matched patients were compared, with no significant difference in the primary endpoint. Perforating CD and preoperative intra-abdominal fistula were associated with PENS failure [37.5 vs 16.1% (P = 0.047) and 41.2% vs 16.2% (P = 0.020), respectively]. After exclusion of these 20 patients, PSM was used to compare 45 'upfront surgery' and 51 'PENS'-matched patients, with a significantly decreased rate of intra-abdominal septic complications and/or temporary defunctioning stoma in the PENS group (19.6 vs 42.2%, P = 0.016). CONCLUSIONS: Preoperative enteral nutritional support is associated with a trend but no conclusive evidence of a reduction in intra-abdominal septic complications and/or requirement for defunctioning stoma. Patients with perforating CD complicated with malnutrition are at risk of PENS failure.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Ministère de la Culture
Université de Lille

Collections :

• Histoire Archéologie Littératures des Mondes Anciens (HALMA) - UMR 8164
• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2021-07-06T12:50:03Z
2024-03-05T10:42:17Z