Author(s) :

Bouillet, Laurence [Auteur]
Defendi, Frederica [Auteur]
Hardy, Gaelle [Auteur]
Cesbron Jean, Yves [Auteur]
Boccon-Gibod, Isabelle [Auteur]
Deroux, Alban [Auteur]
Mansard, Catherine [Auteur]
Launay, David [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Gompel, Anne [Auteur]
Floccard, Bernard [Auteur]
Jaussaud, Roland [Auteur]
Beaudouin, Etienne [Auteur]
Armengol, Guillaume [Auteur]
Ollivier, Yann [Auteur]
Gayet, Stephane [Auteur]
Du-Thanh, Aurelie [Auteur]
Sailler, Laurent [Auteur]
Guez, Stephane [Auteur]
Sarrat, Anne [Auteur]
Sorin, Lucile [Auteur]
De Moreuil, Claire [Auteur]
Pelletier, Fabien [Auteur]
Javaud, Nicolas [Auteur]
Marmion, Nicolas [Auteur]
Fain, Olivier [Auteur]
Faure, Julien [Auteur]
Dumestre-Perard, Chantal [Auteur]

Journal title :

La Presse medicale

Abbreviated title :

Presse Med.

Publication date :

2018-11-08

ISSN :

2213-0276
2213-0276

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Bradykinin mediated angioedema (BK-AE) can be associated either with C1Inhibitor deficiency (hereditary and acquired forms), either with normal C1Inh (hereditary form and drug induced AE as angiotensin converting enzyme ...
Show more >Bradykinin mediated angioedema (BK-AE) can be associated either with C1Inhibitor deficiency (hereditary and acquired forms), either with normal C1Inh (hereditary form and drug induced AE as angiotensin converting enzyme inhibitors...). In case of high clinical suspicion of BK-AE, C1Inh exploration must be done at first: C1Inh function and antigenemy as well as C4 concentration. C1Inh deficiency is significant if the tests are below 50 % of the normal values and controlled a second time. In case of C1Inh deficiency, you have to identify hereditary from acquired forms. C1q and anti-C1Inh antibody tests are useful for acquired BK-AE. SERPING1 gene screening must be done if a hereditary angioedema is suspected, even if there is no family context (de novo mutation 15 %). If a hereditary BK-AE with normal C1Inh is suspected, F12 and PLG gene screening is suitable.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Research team(s) :

Immunity, inflammation and fibrsis in auto and allo-reactivity

Submission date :

2019-03-01T14:07:48Z