Integrated Multi-omic Analysis of ...
Type de document :
Article dans une revue scientifique
PMID :
URL permanente :
Titre :
Integrated Multi-omic Analysis of Esthesioneuroblastomas Identifies Two Subgroups Linked to Cell Ontogeny.
Auteur(s) :
Classe, Marion [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Yao, Hui [Auteur]
Mouawad, Roger [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Creighton Chad, J [Auteur]
Burgess, Alice [Auteur]
Université Paris Diderot - Paris 7 [UPD7]
Allanic, Frederick [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Wassef, Michel [Auteur]
Université Paris Diderot - Paris 7 [UPD7]
Leroy, Xavier [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]
Verillaud, Benjamin [Auteur]
Université Paris Diderot - Paris 7 [UPD7]
Mortuaire, Geoffrey [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Bielle, Franck [Auteur]
Le Tourneau, Christophe [Auteur]
Kurtz, Jean-Emmanuel [Auteur]
Khayat, David [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Su, Xiaoping [Auteur]
Malouf Gabriel, G [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Yao, Hui [Auteur]
Mouawad, Roger [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Creighton Chad, J [Auteur]
Burgess, Alice [Auteur]
Université Paris Diderot - Paris 7 [UPD7]
Allanic, Frederick [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Wassef, Michel [Auteur]
Université Paris Diderot - Paris 7 [UPD7]
Leroy, Xavier [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]
Verillaud, Benjamin [Auteur]
Université Paris Diderot - Paris 7 [UPD7]
Mortuaire, Geoffrey [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Bielle, Franck [Auteur]
Le Tourneau, Christophe [Auteur]
Kurtz, Jean-Emmanuel [Auteur]
Khayat, David [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Su, Xiaoping [Auteur]
Malouf Gabriel, G [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Titre de la revue :
Cell Reports
Nom court de la revue :
Cell Rep
Numéro :
25
Pagination :
811-821.e5
Date de publication :
2018-10-16
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Esthesioneuroblastoma (ENB) is a rare cancer of the olfactory mucosa, with no established molecular stratification to date. We report similarities of ENB with tumors arising in the neural crest and perform integrative ...
Lire la suite >Esthesioneuroblastoma (ENB) is a rare cancer of the olfactory mucosa, with no established molecular stratification to date. We report similarities of ENB with tumors arising in the neural crest and perform integrative analysis of these tumors. We propose a molecular-based subtype classification of ENB as basal or neural, both of which have distinct pathological, transcriptomic, proteomic, and immune features. Among the basal subtype, we uncovered an IDH2 R172 mutant-enriched subgroup ( approximately 35%) harboring a CpG island methylator phenotype reminiscent of IDH2 mutant gliomas. Compared with the basal ENB methylome, the neural ENB methylome shows genome-wide reprogramming with loss of DNA methylation at the enhancers of axonal guidance genes. Our study reveals insights into the molecular pathogenesis of ENB and provides classification information of potential therapeutic relevance.Lire moins >
Lire la suite >Esthesioneuroblastoma (ENB) is a rare cancer of the olfactory mucosa, with no established molecular stratification to date. We report similarities of ENB with tumors arising in the neural crest and perform integrative analysis of these tumors. We propose a molecular-based subtype classification of ENB as basal or neural, both of which have distinct pathological, transcriptomic, proteomic, and immune features. Among the basal subtype, we uncovered an IDH2 R172 mutant-enriched subgroup ( approximately 35%) harboring a CpG island methylator phenotype reminiscent of IDH2 mutant gliomas. Compared with the basal ENB methylome, the neural ENB methylome shows genome-wide reprogramming with loss of DNA methylation at the enhancers of axonal guidance genes. Our study reveals insights into the molecular pathogenesis of ENB and provides classification information of potential therapeutic relevance.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Inserm
Université de Lille
CHU Lille
Université de Lille
CHU Lille
Collections :
Équipe(s) de recherche :
Immunity, inflammation and fibrsis in auto and allo-reactivity
Date de dépôt :
2019-03-01T14:07:54Z
2024-03-05T12:20:56Z
2024-03-05T12:20:56Z
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