Titre :

Extra hepatic cancers are the leading cause of death in cirrhotic patients achieving HBV control or HCV eradication.

Auteur(s) :

Allaire, Manon [Auteur]
Centre de recherche sur l'Inflammation [CRI (UMR_S_1149 / ERL_8252 / U1149)]
Nahon, Pierre [Auteur]
Université Paris 13 [UP13]
Layese, Richard [Auteur]
Université Paris-Est Créteil Val-de-Marne - Faculté de médecine [UPEC Médecine]
Bourcier, Valerie [Auteur]
Cagnot, Carole [Auteur]
ANRS France Recherche Nord & sud Sida-hiv hépatites
Marcellin, Patrick [Auteur]
Guyader, Dominique [Auteur]
Pol, Stanislas [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Larrey, Dominique [Auteur]
De Ledinghen, Victor [Auteur]
Ouzan, Denis [Auteur]
Zoulim, Fabien [Auteur]
Roulot, Dominique [Auteur]
Tran, Albert [Auteur]
Bronowicki, Jean-Pierre [Auteur]
Zarski, Jean-Pierre [Auteur]
Riachi, Ghassan [Auteur]
Cales, Paul [Auteur]
Université d'Angers [UA]
Peron, Jean-Marie [Auteur]
Alric, Laurent [Auteur]
Bourliere, Marc [Auteur]
Mathurin, Philippe [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Blanc, Jean-Frederic [Auteur]
Abergel, Armand [Auteur]
Serfaty, Lawrence [Auteur]
Mallat, Ariane [Auteur]
Université Paris-Est Créteil Val-de-Marne - Paris 12 [UPEC UP12]
Grange, Jean-Didier [Auteur]
Attali, Pierre [Auteur]
Bacq, Yannick [Auteur]
Wartelle, Claire [Auteur]
Dao, Thong [Auteur]
Thabut, Dominique [Auteur]
Pilette, Christophe [Auteur]
Silvain, Christine [Auteur]
Christidis, Christos [Auteur]
Nguyen-Khac, Eric [Auteur]
Bernard-Chabert, Brigitte [Auteur]
Zucman, David [Auteur]
Di Martino, Vincent [Auteur]
Sutton, Angela [Auteur]
Université Paris 13 [UP13]
Letouze, Eric [Auteur]
Génomique Fonctionnelle des Tumeurs Solides [U1162]
Audureau, Etienne [Auteur]
Université Paris-Est Créteil Val-de-Marne - Paris 12 [UPEC UP12]
Roudot-Thoraval, Francoise [Auteur]
Université Paris-Est Créteil Val-de-Marne - Paris 12 [UPEC UP12]

Titre de la revue :

Hepatology (Baltimore, Md.)

Nom court de la revue :

Hepatology

Numéro :

68

Pagination :

1245-1259

Date de publication :

2018-10

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Data on extrahepatic cancers (EHCs) in compensated viral cirrhosis are limited. The objective of the prospective multicenter Agence Nationale de Recherche sur le SIDA et les Hepatites virales CO12 CirVir cohort was to ...
Lire la suite >Data on extrahepatic cancers (EHCs) in compensated viral cirrhosis are limited. The objective of the prospective multicenter Agence Nationale de Recherche sur le SIDA et les Hepatites virales CO12 CirVir cohort was to assess the occurrence of all clinical events in patients with compensated viral cirrhosis, including all types of cancer. Patients with the following inclusion criteria were enrolled in 35 French centers: (1) biopsy-proven hepatitis B virus (HBV) or hepatitis C virus (HCV) cirrhosis, (2) Child-Pugh A, or (3) absence of previous liver complications including primary liver cancer (PLC). Patients were followed up prospectively every 6 months. The standardized mortality ratio (SMR) was calculated according to age and gender using 5-year periods. The impact of sustained viral response (SVR) in HCV patients and maintained viral suppression in HBV patients were assessed using time-dependent analysis. A total of 1,671 patients were enrolled between 2006 and 2012 (median age, 54.9 years; men, 67.3%; HCV, 1,323; HBV, 317; HCV-HBV, 31). Metabolic features and excessive alcohol and tobacco consumption were recorded in 15.2%, 36.4%, and 56.4% of cases, respectively. After a median follow-up of 59.7 months, 227 PLCs were diagnosed (5-year cumulative incidence [CumI] 13.4%) and 93 patients developed EHC (14 patients with lymphoid or related tissue cancer and 79 with solid tissue cancer; 5-year EHC CumI, 5.9%). Compared to the general French population, patients were younger at cancer diagnosis, with significantly higher risk of EHC in HCV patients (SMR, 1.31; 95 confidence interval [CI], 1.04-1.64; P = 0.017) and after SVR (SMR = 1.57; 95% CI, 1.08-2.22; P = 0.013). EHC was the fourth leading cause of death in the whole cohort and the first in patients with viral control/eradication. CONCLUSION: Compared to the general French population, HCV cirrhosis is associated with a higher risk of EHC and the first cause of death in patients with viral cirrhosis who achieve virological control/eradication. (Hepatology 2018).Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Inserm
Université de Lille
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Équipe(s) de recherche :

Inflammatory digestive disease : pathophysiology and therapeutic targets developement

Date de dépôt :

2019-03-01T14:08:14Z
2024-02-06T13:20:41Z