Remodeling of the Candida glabrata cell wall in the gastrointestinal tract affects the gut microbiota and the immune response

Charlet, Rogatien; Pruvost, Youri; Tumba, Gael; Istel, Fabian; Poulain, Daniel; Kuchler, Karl; Sendid, Boualem; Jawhara, Samir

Type de document :

Article dans une revue scientifique

DOI :

10.1038/s41598-018-21422-w

PMID :

29463799

URL permanente :

http://hdl.handle.net/20.500.12210/4542

Titre :

Remodeling of the Candida glabrata cell wall in the gastrointestinal tract affects the gut microbiota and the immune response

Auteur(s) :

Charlet, Rogatien [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Lille Inflammation Research International Center - U 995 [LIRIC]
Pruvost, Youri [Auteur]
Tumba, Gael [Auteur]
Istel, Fabian [Auteur]
Poulain, Daniel [Auteur]

Kuchler, Karl [Auteur]
Sendid, Boualem [Auteur]

Lille Inflammation Research International Center - U 995 [LIRIC]
Lille Inflammation Research International Center (LIRIC) - U995
Jawhara, Samir [Auteur]

Titre de la revue :

Scientific Reports

Nom court de la revue :

Sci Rep

Numéro :

Date de publication :

2018-02-20

ISSN :

2045-2322
2045-2322

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

The gastrointestinal (GI) microbiota acts a natural barrier to the proliferation of opportunistic pathogens. Candida glabrata is an opportunistic yeast pathogen that has adapted to colonize all segments of the human GI ...
Lire la suite >The gastrointestinal (GI) microbiota acts a natural barrier to the proliferation of opportunistic pathogens. Candida glabrata is an opportunistic yeast pathogen that has adapted to colonize all segments of the human GI tract. We observed an increase in Escherichia coli, Enterococcus faecalis, and Bacteroides vulgatus populations, and a decrease in Lactobacillus johnsonii, Bacteroides thetaiotaomicron, and Bifidobacterium animalis in mice with DSS-induced colitis. This reduction was more pronounced for L. johnsonii during C. glabrata overgrowth. In addition, C. glabrata overgrowth increased mouse mortality and inflammatory parameters, and modulated the expression of intestinal receptors and signaling pathways. The C. glabrata cell wall underwent various changes during the course of C. glabrata colonization, and showed a significant increase in chitin. C. glabrata deficient in chitin synthase-3 induced fewer inflammatory parameters than the parental strain during intestinal inflammation. Oral administration of chitin attenuated the impact of colitis, and reduced the number of aerobic bacteria and C. glabrata overgrowth, while chitinase-3-like protein-1 increased. This study provides evidence that inflammation of the gut alters the microbial balance and leads to C. glabrata cell wall remodeling through an increase in chitin, which is involved in promoting persistence of C. glabrata in the gut.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Inserm
Université de Lille
CHU Lille

Collections :

Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Équipe(s) de recherche :

Fungal associated invasive and inflammatory diseases

Date de dépôt :

2019-03-01T14:08:19Z

Numéro de version	Lien	Date de modification
2	20.500.12210/4542	2024-03-05T15:37:00Z
1	20.500.12210/4542.1*	2019-03-01T14:08:19Z

Remodeling of the Candida glabrata cell ...

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Remodeling of the Candida glabrata cell ...

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