Title :

Disease course of inflammatory bowel disease unclassified in a European population-based inception cohort - an Epi-IBD study.

Author(s) :

Burisch, Johan [Auteur]
Zammit Stefania, Chetcuti [Auteur]
Ellul, Pierre [Auteur]
Turcan, Svetlana [Auteur]
Duricova, Dana [Auteur]
Bortlik, Martin [Auteur]
Winther Andersen, Karina [Auteur]
Andersen, Vibeke [Auteur]
Kaimakliotis Ioannis, P [Auteur]
Fumery, Mathurin [Auteur]
Gower, Corinne [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Girardin, Giulia [Auteur]
Valpiani, Daniela [Auteur]
Goldis, Adrian [Auteur]
Brinar, Marko [Auteur]
Cukovic-Cavka, Silvija [Auteur]
Oksanen, Pia [Auteur]
Collin, Pekka [Auteur]
Barros, Luisa [Auteur]
Magro, Fernando [Auteur]
Misra, Ravi [Auteur]
Arebi, Naila [Auteur]
Eriksson, Carl [Auteur]
Halfvarson, Jonas [Auteur]
Kievit Hendrika Adriana, Linda [Auteur]
Pedersen, Natalia [Auteur]
Kjeldsen, Jens [Auteur]
Myers, Sally [Auteur]
Sebastian, Shaji [Auteur]
Katsanos Konstantinos, H [Auteur]
Christodoulou Dimitrios, K [Auteur]
Midjord, Jongerð [Auteur]
Nielsen Kari, Rubek [Auteur]
Kiudelis, Gediminas [Auteur]
Kupcinskas, Limas [Auteur]
Nikulina, Inna [Auteur]
Belousova, Elena [Auteur]
Schwartz, Doron [Auteur]
Odes, Selwyn [Auteur]
Salupere, Riina [Auteur]
Carmona, Amalia [Auteur]
Pineda Juan, R [Auteur]
Vegh, Zsuzsanna [Auteur]
Lakatos Peter, Laszlo [Auteur]
Langholz, Ebbe [Auteur]
Munkholm, Pia [Auteur]

Journal title :

Journal of gastroenterology and hepatology

Abbreviated title :

J. Gastroenterol. Hepatol.

Publication date :

2018-12-18

ISSN :

1440-1746

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

BACKGROUND: A definitive diagnosis of Crohn's disease (CD) or ulcerative colitis (UC) is not always possible and a proportion of patients will be diagnosed as inflammatory bowel disease unclassified (IBDU). The aim of ...
Show more >BACKGROUND: A definitive diagnosis of Crohn's disease (CD) or ulcerative colitis (UC) is not always possible and a proportion of patients will be diagnosed as inflammatory bowel disease unclassified (IBDU). The aim of the study was to investigate the prognosis of patients initially diagnosed with IBDU and the disease course during the following five years. METHODS: The Epi-IBD study is a prospective population-based cohort of 1,289 IBD patients diagnosed in centres across Europe. Clinical data were captured prospectively throughout the follow-up period. RESULTS: Overall, 476 (37%) patients were initially diagnosed with CD, 701 (54%) with UC, and 112 (9%) with IBDU. During follow-up, 28 (25%) IBDU patients were changed diagnoses to either UC (n=20, 71%) or CD (n=8, 29%) after a median of six months (IQR: 4-12), while 84 (7% of the total cohort) remained IBDU. A total of 17 (15%) IBDU patients were hospitalized for their IBD during follow-up, while 8 (7%) patients underwent surgery. Most surgeries (n=6, 75%) were performed on patients whose diagnosis was later changed to UC; three of these colectomies led to a definitive diagnosis of UC. Most patients (n=107, 96%) received 5-aminosalicylic acid, while 11 (10%) patients received biologicals, of whom five remained classified as IBDU. CONCLUSIONS: In a population-based inception cohort, 7% of IBD patients were not given a definitive diagnosis of IBD after five years of follow-up. One in four patients with IBDU eventually were classified as CD or UC. Overall, the disease course and medication burden in IBDU patients were mild.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Research team(s) :

Inflammatory digestive disease : pathophysiology and therapeutic targets developement
IBD and environnemental factors : epidemiology and functional analyses

Submission date :

2019-03-01T14:17:31Z