Title :

Prognostic value of viral eradication for major adverse cardiovascular events in hepatitis C cirrhotic patients.

Author(s) :

Cacoub, Patrice [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Nahon, Pierre [Auteur]
Génomique Fonctionnelle des Tumeurs Solides [U1162]
Layese, Richard [Auteur]
Université Paris-Est Créteil Val-de-Marne - Paris 12 [UPEC UP12]
Blaise, Lorraine [Auteur]
Desbois Anne, Claire [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Bourcier, Valerie [Auteur]
Cagnot, Carole [Auteur]
Agence Nationale de Recherches sur le Sida et les Hépatites Virales [ANRS]
Marcellin, Patrick [Auteur]
Guyader, Dominique [Auteur]
Pol, Stanislas [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Larrey, Dominique [Auteur]
De Ledinghen, Victor [Auteur]
Ouzan, Denis [Auteur]
Zoulim, Fabien [Auteur]
Roulot, Dominique [Auteur]
Tran, Albert [Auteur]
Bronowicki, Jean-Pierre [Auteur]
Zarski, Jean-Pierre [Auteur]
Riachi, Ghassan [Auteur]
Cales, Paul [Auteur]
Peron, Jean-Marie [Auteur]
Alric, Laurent [Auteur]
Université Toulouse III - Paul Sabatier [UT3]
Bourliere, Marc [Auteur]
Mathurin, Philippe [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Blanc, Jean-Frederic [Auteur]
Abergel, Armand [Auteur]
Serfaty, Lawrence [Auteur]
Mallat, Ariane [Auteur]
Grange, Jean-Didier [Auteur]
Attali, Pierre [Auteur]
Bacq, Yannick [Auteur]
Wartelle, Claire [Auteur]
Dao, Thong [Auteur]
Thabut, Dominique [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Pilette, Christophe [Auteur]
Silvain, Christine [Auteur]
Christidis, Christos [Auteur]
Capron, Dominique [Auteur]
Thiefin, Gerard [Auteur]
Zucman, David [Auteur]
Di Martino, Vincent [Auteur]
Bagnis Corinne, Isnard [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Ziol, Marianne [Auteur]
Génomique Fonctionnelle des Tumeurs Solides [U1162]
Sutton, Angela [Auteur]
Letouze, Eric [Auteur]
Génomique Fonctionnelle des Tumeurs Solides [U1162]
Roudot-Thoraval, Francoise [Auteur]
Université Paris-Est Créteil Val-de-Marne - Paris 12 [UPEC UP12]
Audureau, Etienne [Auteur]
Université Paris-Est Créteil Val-de-Marne - Paris 12 [UPEC UP12]

Journal title :

American Heart Journal

Abbreviated title :

Am. Heart J.

Volume number :

198

Pages :

4-17

Publication date :

2018-04

ISSN :

1097-6744

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

BACKGROUND: The objective was to examine the role of a sustained virological response (SVR) on major adverse cardiovascular events (MACEs) in patients with compensated hepatitis C virus (HCV) cirrhosis. METHODS: Patients ...
Show more >BACKGROUND: The objective was to examine the role of a sustained virological response (SVR) on major adverse cardiovascular events (MACEs) in patients with compensated hepatitis C virus (HCV) cirrhosis. METHODS: Patients with the following criteria were enrolled in 35 French centers: (1) biopsy-proven HCV cirrhosis; (2) Child-Pugh A; (3) positive viremia; and (4) no prior liver complication, and then prospectively followed. All patients received HCV treatment after inclusion. MACEs included stroke, myocardial infarction, ischemic heart disease, heart failure, peripheral arterial disease, cardiac arrest, and cardiovascular death. SVR, defined as negative viremia 12 weeks posttreatment, was considered as a time-dependent covariate, and its effect on MACE occurrence was assessed. The median follow up was 57.5 months, ending in December 2015. RESULTS: Sixty-two of 878 (7.1%) patients presented a total of 79 MACEs. The main predictive baseline factors of MACEs were Asian ethnic origin, history of MACEs, arterial hypertension, diabetes mellitus, current smoking, low serum albumin level, high total bilirubin level, and low platelet count. In multivariate analysis, SVR was associated with a decreased risk of MACEs (hazard ratio=0.35, 95% CI 0.09-0.97, P=.044), whereas Asian ethnic origin, arterial hypertension, smoking, and low serum albumin level remained predictive of MACE occurrence. The 5-year survival rate was 60.1% versus 87.5% in patients who did versus those who did not present a MACE (P<.001). CONCLUSIONS: In patients with compensated HCV-related cirrhosis, Asian ethnic origin, arterial hypertension, smoking, and low serum albumin are independent predictive factors of cardiovascular events, whereas an SVR is associated with a decreased rate of cardiovascular events.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Research team(s) :

Inflammatory digestive disease : pathophysiology and therapeutic targets developement

Submission date :

2019-03-01T14:17:54Z
2024-02-01T13:41:06Z