Title :

Diagnostic performance of a new noninvasive test for nonalcoholic steatohepatitis using a simplified histological reference.

Author(s) :

Poynard, Thierry [Auteur]
Centre de Recherche Saint-Antoine [UMRS893]
Munteanu, Mona [Auteur]
BioPredictive [Paris]
Charlotte, Frederic [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Perazzo, Hugo [Auteur]
Centre de Recherche Saint-Antoine [UMRS893]
Ngo, Yen [Auteur]
BioPredictive [Paris]
Deckmyn, Olivier [Auteur]
BioPredictive [Paris]
Pais, Raluca [Auteur]
Centre de Recherche Saint-Antoine [UMRS893]
Merrouche, Wassil [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
De Ledinghen, Victor [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Mathurin, Philippe [Auteur]
498252|||Lille Inflammation Research International Center - U 995 [LIRIC]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Ratziu, Vlad [Auteur]
Centre de Recherche Saint-Antoine [UMRS893]
De Ledinghen, Victor [Auteur]

Journal title :

European Journal of Gastroenterology & Hepatology

Abbreviated title :

Eur. J. Gastroenterol. Hepatol.

Volume number :

30

Pages :

569-577

Publication date :

2018-02-05

Keyword(s) :

NASH
nonalcoholic fatty liver disease
SAF scoring system
ActiTest
Clinical Research Network
nonalcoholic steatohepatitis
Fatty Liver Inhibition of Progression algorithm
metabolic liver disease
FibroTest

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background One of the unmet needs in patients with metabolic risks is the prediction of metabolic liver disease (MLD) by noninvasive tests (NITs). Objective The primary aim of this study was to construct a new ...
Show more >Background One of the unmet needs in patients with metabolic risks is the prediction of metabolic liver disease (MLD) by noninvasive tests (NITs). Objective The primary aim of this study was to construct a new quantitative test for the diagnosis of nonalcoholic steatohepatitis (NASH) using a simplified histological definition. Patients and methods As a reference, we used a simplified histological definition of NASH derived from the FLIP-CRN-definition that does not require the presence of steatosis and the presence of both lobular inflammation and ballooning. We analyzed 1081 patients from two prospective cohorts at risk of MLD who had biopsies and contemporaneous blood samples. These patients were divided randomly into a training group (n=541) and a control group (n=540) for internal validation. The new test was compared with standard tests, and applied in two large populations at risk of MLD. Results Out of 1081 patients with biopsy, 39 (3.6%) cases with significant inflammatory activity or fibrosis (A2orF2) were missed by the current histological definitions. The combination of 11 parameters permitted to construct a test (NIT-NASHs) predicting NASH with an area under the receiver operating characteristic curve (AUROC) of 0.773 (95% confidence interval: 0.730–0.810), confirmed in the control group 0.814 (0.774–0.847). The AUROCs of NIT-NASHs were higher (all P<0.001) than those of ActiTest, FIB4, BARD, and nonalcoholic fatty liver disease scores. A combination of NIT-NASHs with FibroTest (AUROC=0.800; 0.759–0.835) enabled a better prediction (P<0.0001) of significant MLD, A2orF2, than the ActiTest–FibroTest combination. Conclusion These results suggested that this new test enables a quantitative assessment of NASH, and when associated with the FibroTest, identifies cases with clinically significant MLD. An external validation is needed.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Research team(s) :

Inflammatory digestive disease : pathophysiology and therapeutic targets developement

Submission date :

2019-03-01T14:34:50Z
2024-01-19T11:07:45Z