Title :

Multicenter assessment of exclusive endoscopic endonasal approach for the treatment of 53 olfactory neuroblastomas.

Author(s) :

De Gabory, Ludovic [Auteur]
Verillaud, Benjamin [Auteur]
Rumeau, Cecile [Auteur]
Herman, Philippe [Auteur]
Jankowski, Roger [Auteur]
Michel, Justin [Auteur]
De Kermadec, Heloise [Auteur]
Coste, Andre [Auteur]
Mortuaire, Geoffrey [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Righini, Christian [Auteur]
Reyt, Emile [Auteur]
Choussy, Olivier [Auteur]
Trevillot, Vincent [Auteur]
Crampette, Louis [Auteur]
Université de Montpellier [UM]
Serrano, Elie [Auteur]
Tsaranazy, Anjarasoa [Auteur]
Bastier, Pierre-Louis [Auteur]
Vergez, Sebastien [Auteur]

Journal title :

Head & Neck

Abbreviated title :

Head Neck

Volume number :

40

Pages :

1000-1007

Publication date :

2018-05

Keyword(s) :

sinus cancer
olfactory cleft
neuroblastoma
endoscopic surgery

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background Given the particularities of olfactory neuroblastoma (ONB) and the lack of studies on the subject, a multicenter collaborative study was conducted to assess treatment strategy. Methods Fifty-three patients ...
Show more >Background Given the particularities of olfactory neuroblastoma (ONB) and the lack of studies on the subject, a multicenter collaborative study was conducted to assess treatment strategy. Methods Fifty-three patients with ONB were included from the French Rare Head and Neck Cancer Expert Network (REFCOR) database: 16T1, 8T2, 19T3, and 10T4. All cases were treated endoscopically with skull base removal and repair in 26 cases (49%) and without external craniotomy. Results The overall survival (OS) and disease-free survival (DFS) rates at 5 years were 87% and 71%, respectively, with mean follow-up of 45.4 ± 26.5 months. The complication rate was 18.8% with 4 cases of meningitis. Pathological analysis showed positive margins in 26.8%, notably on the dura-mater and periorbita, without impairment of OS or DFS. Forty-eight patients received adjuvant radiotherapy on T ± N. Ten patients had a recurrence (18.9%). Six patients died of their disease. Prophylactic neck irradiation seemed to reduce the recurrence rate. Conclusion Exclusively endoscopic treatment proved efficient and reliable in a large controlled series.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Research team(s) :

Immunity, inflammation and fibrsis in auto and allo-reactivity

Submission date :

2019-03-01T14:34:51Z
2024-03-06T10:42:33Z