Multicenter assessment of exclusive ...
Document type :
Article dans une revue scientifique
DOI :
PMID :
Permalink :
Title :
Multicenter assessment of exclusive endoscopic endonasal approach for the treatment of 53 olfactory neuroblastomas.
Author(s) :
De Gabory, Ludovic [Auteur]
Verillaud, Benjamin [Auteur]
Rumeau, Cecile [Auteur]
Herman, Philippe [Auteur]
Jankowski, Roger [Auteur]
Michel, Justin [Auteur]
De Kermadec, Heloise [Auteur]
Coste, Andre [Auteur]
Mortuaire, Geoffrey [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Righini, Christian [Auteur]
Reyt, Emile [Auteur]
Choussy, Olivier [Auteur]
Trevillot, Vincent [Auteur]
Crampette, Louis [Auteur]
Université de Montpellier [UM]
Serrano, Elie [Auteur]
Tsaranazy, Anjarasoa [Auteur]
Bastier, Pierre-Louis [Auteur]
Vergez, Sebastien [Auteur]
Verillaud, Benjamin [Auteur]
Rumeau, Cecile [Auteur]
Herman, Philippe [Auteur]
Jankowski, Roger [Auteur]
Michel, Justin [Auteur]
De Kermadec, Heloise [Auteur]
Coste, Andre [Auteur]
Mortuaire, Geoffrey [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Righini, Christian [Auteur]
Reyt, Emile [Auteur]
Choussy, Olivier [Auteur]
Trevillot, Vincent [Auteur]
Crampette, Louis [Auteur]
Université de Montpellier [UM]
Serrano, Elie [Auteur]
Tsaranazy, Anjarasoa [Auteur]
Bastier, Pierre-Louis [Auteur]
Vergez, Sebastien [Auteur]
Journal title :
Head & Neck
Abbreviated title :
Head Neck
Volume number :
40
Pages :
1000-1007
Publication date :
2018-05
Keyword(s) :
sinus cancer
olfactory cleft
neuroblastoma
endoscopic surgery
olfactory cleft
neuroblastoma
endoscopic surgery
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Background
Given the particularities of olfactory neuroblastoma (ONB) and the lack of studies on the subject, a multicenter collaborative study was conducted to assess treatment strategy.
Methods
Fifty-three patients ...
Show more >Background Given the particularities of olfactory neuroblastoma (ONB) and the lack of studies on the subject, a multicenter collaborative study was conducted to assess treatment strategy. Methods Fifty-three patients with ONB were included from the French Rare Head and Neck Cancer Expert Network (REFCOR) database: 16T1, 8T2, 19T3, and 10T4. All cases were treated endoscopically with skull base removal and repair in 26 cases (49%) and without external craniotomy. Results The overall survival (OS) and disease-free survival (DFS) rates at 5 years were 87% and 71%, respectively, with mean follow-up of 45.4 ± 26.5 months. The complication rate was 18.8% with 4 cases of meningitis. Pathological analysis showed positive margins in 26.8%, notably on the dura-mater and periorbita, without impairment of OS or DFS. Forty-eight patients received adjuvant radiotherapy on T ± N. Ten patients had a recurrence (18.9%). Six patients died of their disease. Prophylactic neck irradiation seemed to reduce the recurrence rate. Conclusion Exclusively endoscopic treatment proved efficient and reliable in a large controlled series.Show less >
Show more >Background Given the particularities of olfactory neuroblastoma (ONB) and the lack of studies on the subject, a multicenter collaborative study was conducted to assess treatment strategy. Methods Fifty-three patients with ONB were included from the French Rare Head and Neck Cancer Expert Network (REFCOR) database: 16T1, 8T2, 19T3, and 10T4. All cases were treated endoscopically with skull base removal and repair in 26 cases (49%) and without external craniotomy. Results The overall survival (OS) and disease-free survival (DFS) rates at 5 years were 87% and 71%, respectively, with mean follow-up of 45.4 ± 26.5 months. The complication rate was 18.8% with 4 cases of meningitis. Pathological analysis showed positive margins in 26.8%, notably on the dura-mater and periorbita, without impairment of OS or DFS. Forty-eight patients received adjuvant radiotherapy on T ± N. Ten patients had a recurrence (18.9%). Six patients died of their disease. Prophylactic neck irradiation seemed to reduce the recurrence rate. Conclusion Exclusively endoscopic treatment proved efficient and reliable in a large controlled series.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Inserm
Université de Lille
CHU Lille
Université de Lille
CHU Lille
Research team(s) :
Immunity, inflammation and fibrsis in auto and allo-reactivity
Submission date :
2019-03-01T14:34:51Z
2024-03-06T10:42:33Z
2024-03-06T10:42:33Z