Coxsackievirus B4 Can Infect Human Peripheral Blood- Derived Macrophages

Alidjinou, Enagnon-Kazali; Sane, Famara; Trauet, Jacques; Copin, Marie-Christine; Hober, Didier

Document type :

Article dans une revue scientifique

DOI :

10.3390/v7112924

PMID :

26610550

Permalink :

http://hdl.handle.net/20.500.12210/5250

Title :

Coxsackievirus B4 Can Infect Human Peripheral Blood- Derived Macrophages

Author(s) :

Alidjinou, Enagnon-Kazali [Auteur]

Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Sane, Famara [Auteur]

Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Trauet, Jacques [Auteur]

Lille Inflammation Research International Center - U 995 [LIRIC]
Copin, Marie-Christine [Auteur]

Mécanismes de la Tumorigénèse et Thérapies Ciblées - UMR 8161 [M3T]
Hober, Didier [Auteur]

Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]

Journal title :

Viruses

Abbreviated title :

Viruses-Basel

Volume number :

Pages :

6067-6079

Publication date :

2015-11-24

ISSN :

1999-4915

Keyword(s) :

persistence
inflammation
GM-CSF
monocyte-derived macrophages
M-CSF
infection
coxsackievirus B

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Beyond acute infections, group B coxsackieviruses (CVB) are also reported to play a role in the development of chronic diseases, like type 1 diabetes. The viral pathogenesis mainly relies on the interplay between the viruses ...
Show more >Beyond acute infections, group B coxsackieviruses (CVB) are also reported to play a role in the development of chronic diseases, like type 1 diabetes. The viral pathogenesis mainly relies on the interplay between the viruses and innate immune response in genetically-susceptible individuals. We investigated the interaction between CVB4 and macrophages considered as major players in immune response. Monocyte-derived macrophages (MDM) generated with either M-CSF or GM-CSF were inoculated with CVB4, and infection, inflammation, viral replication and persistence were assessed. M-CSF-induced MDM, but not GM-CSF-induced MDM, can be infected by CVB4. In addition, enhancing serum was not needed to infect MDM in contrast with parental monocytes. The expression of viral receptor (CAR) mRNA was similar in both M-CSF and GM-CSF MDM. CVB4 induced high levels of pro-inflammatory cytokines (IL-6 and TNFα) in both MDM populations. CVB4 effectively replicated and persisted in M-CSF MDM, but IFNα was produced in the early phase of infection only. Our results demonstrate that CVB4 can replicate and persist in MDM. Further investigations are required to determine whether the interaction between the virus and MDM plays a role in the pathogenesis of CVB-induced chronic diseases.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille
CNRS

Collections :

Research team(s) :

Immunity, inflammation and fibrsis in auto and allo-reactivity

Submission date :

2019-03-01T15:15:48Z
2022-11-16T09:53:40Z

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Except where otherwise noted, this item's license is described as Attribution 3.0 United States

Version	Link	Modification date
2	20.500.12210/5250*	2022-11-16T09:46:36Z
1	20.500.12210/5250.1	2019-03-01T15:15:48Z

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Coxsackievirus B4 Can Infect Human Peripheral ...

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