Title :

Large-vessel involvement and aortic dilation in giant-cell arteritis. A multicenter study of 549 patients.

Author(s) :

De Boysson, Hubert [Auteur]
Université de Caen Normandie [UNICAEN]
Daumas, Aurelie [Auteur]
Vautier, Mathieu [Auteur]
Parienti, Jean-Jacques [Auteur]
Liozon, Eric [Auteur]
Lambert, Marc [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Samson, Maxime [Auteur]
Ebbo, Mikael [Auteur]
Dumont, Anael [Auteur]
Sultan, Audrey [Auteur]
Bonnotte, Bernard [Auteur]
Manrique, Alain [Auteur]
Bienvenu, Boris [Auteur]
Saadoun, David [Auteur]
Aouba, Achille [Auteur]
Université de Caen Normandie [UNICAEN]
Aouba, Achille [Auteur]

Journal title :

Autoimmunity reviews

Abbreviated title :

Autoimmun. Rev.

Volume number :

17

Pages :

391-398

Publication date :

2018-04

Keyword(s) :

Giant-cell arteritis
Aortic dilation
Aortitis
Large-vessel involvement

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Objectives Large-vessel involvement (LVI) can occur in giant-cell arteritis (GCA) and may represent a distinct disease subgroup with a higher risk for aortic dilation. This study aimed to better characterize the presentation ...
Show more >Objectives Large-vessel involvement (LVI) can occur in giant-cell arteritis (GCA) and may represent a distinct disease subgroup with a higher risk for aortic dilation. This study aimed to better characterize the presentation and evolution of LVI in patients with GCA. Patients and methods A retrospective multicenter study enrolled 248 GCA patients with LVI and 301 GCA patients without LVI on imaging. Factors associated with aortic dilation were identified in a multivariable model. Results The patients with LVI were younger (p < 0.0001), more likely to be women (p = 0.01), and showed fewer cephalic symptoms (p < 0.0001) and polymyalgia rheumatica (p = 0.001) but more extracranial vascular symptoms (p = 0.05) than the patients without LVI. Glucocorticoids (GC) management did not differ between the two groups, but the GC discontinuation rate was lower in the patients with LVI (p = 0.0003). Repeated aortic imaging procedures were performed at 19 months [range: 5–162 months] and 17 months [range: 6–168 months] after diagnosis in 154 patients with LVI and 123 patients without LVI, respectively, of whom 21% and 7%, respectively, presented new aortic dilations (p = 0.0008). In the patients with LVI, aortic dilation occurred on an aorta segment shown to be inflammatory on previous imaging in 94% of patients. In the multivariate analysis, LVI was the strongest predictor of aortic dilation (hazard ratio: 3.16 [range: 1.34–7.48], p = 0.009). Conclusions LVI represents a distinct disease pattern of GCA with an increased risk of aortic dilation. Control of the aortic morphology during follow-up is required.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille

Collections :

• Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Research team(s) :

Glycation from inflammation to aging

Submission date :

2019-03-01T15:24:45Z
2024-03-05T11:17:34Z