Title :

Low-grade systemic inflammation: a partial mediator of the relationship between diabetes and lung function

Author(s) :

Giovannelli, Jonathan [Auteur]
Trouiller-Gerfaux, Philippe [Auteur]
Hulo, Sebastien [Auteur]
Cherot, Nathalie [Auteur]
Ciuchete, Alina [Auteur]
Edme, Jean-Louis [Auteur]
IMPact de l’Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483
Matran, Regis [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Amouyel, Philippe [Auteur]
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Meirhaeghe, Aline [Auteur]
Dauchet, Luc [Auteur]
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167

Journal title :

Annals of epidemiology

Abbreviated title :

Ann. Epidemiol.

Volume number :

28

Pages :

26-32

Publication date :

2018-01-01

ISSN :

1047-2797

Keyword(s) :

Lung function
Diabetes complication
Mediation analysis
Inflammation
C-reactive protein

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

An association has been consistently found between diabetes mellitus and decreased lung function. We evaluated to what extent low-grade inflammation (as measured by the level of high-sensitivity C-reactive protein [hs-CRP]) ...
Show more >An association has been consistently found between diabetes mellitus and decreased lung function. We evaluated to what extent low-grade inflammation (as measured by the level of high-sensitivity C-reactive protein [hs-CRP]) could explain this relationship. A sample of 1878 middle-aged adults from the cross-sectional Enquête Littoral Souffle Air Biologie Environnement survey without self-reported pulmonary and atherosclerosis disease was included. A mediation analysis was performed to assess and quantify the hs-CRP level as a mediator of the relationship between diabetes and lung function. Diabetes was associated with higher hs-CRP level (+22.9%, 95% confidence interval = [5.1, 43.6]). The hs-CRP (>4 vs. ≤1 mg/L) was associated with lower percentage predicted values for the forced expiratory volume in the first second (FEV1) (-4% [-6.1, -1.9]) and forced vital capacity (FVC) (-4.4% [-6.5, -2.3]). Diabetes was associated with FEV1 (-3.5% [-5.8, -1.3]) and FVC (-3.6% [-5.9, -1.3]). The proportion of the effect that is mediated by hs-CRP was 12% [2.4, 37] and 13% [3.7, 39.4] for FEV1 and FVC, respectively. Our results suggest that low-grade systemic inflammation could only explain a small part of the relationship between diabetes and lung function.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Institut Pasteur de Lille
Université de Lille

Collections :

• Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2022-02-02T10:23:30Z