Title :

Prognostic value of microscopic hematuria after induction of remission in antineutrophil cytoplasmic antibodies-associated vasculitis

Author(s) :

Vandenbussche, Cyrille [Auteur]
Bitton, Laura [Auteur]
Bataille, Pierre [Auteur]
Centre Hospitalier Boulogne-sur-mer
Glowacki, Francois [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Azar, Raymond [Auteur]
Hatron, Pierre-Yves [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Macnamara, Evelyne [Auteur]
Gheerbrant, Jean-Dominique [Auteur]
Cardon, Gerard [Auteur]
Hoffmann, Maxime [Auteur]
Auxenfants, Eric [Auteur]
Gnemmi, Viviane [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172
Quemeneur, Thomas [Auteur]

Journal title :

American Journal of Nephrology

Abbreviated title :

Am. J. Nephrol.

Volume number :

49

Pages :

479-486

Publisher :

Karger

Publication date :

2019-05-22

ISSN :

0250-8095

Keyword(s) :

Hematuria
Renal relapse
Antineutrophil cytoplasmic antibodies-associated vasculitis
Pauci-immune glomerulonephritis

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Pauci-immune glomerulonephritis (PIGN) is a major prognostic factor in antineutrophil cytoplasmic antibodies-associated vasculitis (AAV). Renal remission is usually defined as improvement or stabilization of serum creatinine ...
Show more >Pauci-immune glomerulonephritis (PIGN) is a major prognostic factor in antineutrophil cytoplasmic antibodies-associated vasculitis (AAV). Renal remission is usually defined as improvement or stabilization of serum creatinine and proteinuria levels but the significance of hematuria is unclear. We evaluated the prognostic value of microscopic hematuria in patients in remission from a first flare of PIGN. A multicenter retrospective study was conducted of all patients with histologically proven PIGN in northern France who presented a first renal flare of AAV between 2003 and 2013. All patients received conventional induction treatment and were considered in remission. Two groups were defined by the presence (H+) or absence (H-) of hematuria (dipstick 1+ and/or cytology ≥10,000 erythrocytes/mL). The primary outcome measure was the occurrence of renal relapse (RR) and/or end-stage renal disease (ESRD). Eighty-six patients were included: 41 (48%) had hematuria at remission. The median follow-up time was 44 ± 34 months. There was no significant difference between the groups in terms of the primary endpoint or the number of RR. However, the survival rate without RR was significantly lower in the H+ group (p = 0.002). In multivariate analysis, risk factors for RR were hematuria at remission for relapses within 44 months (hazard ratio [HR] 4.15; 95% CI 1.15-15.01; p = 0.03) and the duration of maintenance immunosuppressive therapy (HR 0.96 per additional month; 95% CI 0.94-0.99; p = 0.002). Hematuria at remission after a first PIGN flare was not associated with ESRD but with the occurrence of RR within 44 months of remission.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CNRS
Université de Lille

Collections :

• Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277
• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
• Miniaturisation pour la Synthèse, l'Analyse et la Protéomique (MSAP) - USR 3290

Submission date :

2022-02-02T10:24:02Z
2024-03-13T08:31:42Z