Comparison of biomarker for diagnosis of ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Comparison of biomarker for diagnosis of nitrous oxide abuse: challenge of cobalamin metabolic parameters, a retrospective study.
Auteur(s) :
Grzych, Guillaume [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Deheul, Sylvie [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Gernez, Emeline [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Davion, Jean-Baptiste [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Dobbelaere, Dries [Auteur]
Maladies RAres du DEveloppement embryonnaire et du MEtabolisme : du Phénotype au Génotype et à la Fonction - ULR 7364 [RADEME]
Hôpital Jeanne de Flandres
Carton, Louise [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Kim, Isabelle [Auteur]
Guichard, Jean Claude [Auteur]
Girot, Marie [Auteur]
Humbert, Linda [Auteur]
Bennis, Anas [Auteur]
Centre Hospitalier de Roubaix
Joncquel, Marie [Auteur]
Maladies Rares du Développement : Génétique, Régulation et Protéomique (RADEME) - ULR 7364
Chieux, Vincent [Auteur]
Joly, Audrey [Auteur]
Nasserdine, Phénicia [Auteur]
Trillot, Nathalie [Auteur]
Douillard, Claire [Auteur]
Maladies RAres du DEveloppement embryonnaire et du MEtabolisme : du Phénotype au Génotype et à la Fonction - ULR 7364 [RADEME]
Service Endocrinologie, diabétologie, maladies métaboliques et nutrition [LILLE - Endocrino]
Hôpital Jeanne de Flandres
Pigny, Pascal [Auteur]
Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Tard, Celine [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Centre de référence des maladies rares neuromusculaires
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Deheul, Sylvie [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Gernez, Emeline [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Davion, Jean-Baptiste [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Dobbelaere, Dries [Auteur]
Maladies RAres du DEveloppement embryonnaire et du MEtabolisme : du Phénotype au Génotype et à la Fonction - ULR 7364 [RADEME]
Hôpital Jeanne de Flandres
Carton, Louise [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Kim, Isabelle [Auteur]
Guichard, Jean Claude [Auteur]
Girot, Marie [Auteur]
Humbert, Linda [Auteur]
Bennis, Anas [Auteur]
Centre Hospitalier de Roubaix
Joncquel, Marie [Auteur]
Maladies Rares du Développement : Génétique, Régulation et Protéomique (RADEME) - ULR 7364
Chieux, Vincent [Auteur]
Joly, Audrey [Auteur]
Nasserdine, Phénicia [Auteur]
Trillot, Nathalie [Auteur]
Douillard, Claire [Auteur]
Maladies RAres du DEveloppement embryonnaire et du MEtabolisme : du Phénotype au Génotype et à la Fonction - ULR 7364 [RADEME]
Service Endocrinologie, diabétologie, maladies métaboliques et nutrition [LILLE - Endocrino]
Hôpital Jeanne de Flandres
Pigny, Pascal [Auteur]
Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Tard, Celine [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Centre de référence des maladies rares neuromusculaires
Titre de la revue :
Journal of Neurology
Nom court de la revue :
J Neurol
Date de publication :
2023-01-24
ISSN :
1432-1459
Mot(s)-clé(s) en anglais :
Nitrous oxide
N2O
Cobalamin
Vitamin B12
Homocysteine
Methylmalonic acid
Biological markers
Neurology
Neuropathy
N2O
Cobalamin
Vitamin B12
Homocysteine
Methylmalonic acid
Biological markers
Neurology
Neuropathy
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Background
Recreational use of nitrous oxide (N2O) leads to neurological disorders including combined subacute degeneration of spinal cord, psychological disorders, and thrombosis. Serum or urine N2O assays could not be ...
Lire la suite >Background Recreational use of nitrous oxide (N2O) leads to neurological disorders including combined subacute degeneration of spinal cord, psychological disorders, and thrombosis. Serum or urine N2O assays could not be routinely performed. Hence, it is necessary to investigate other biological markers such as metabolic markers. We aimed here to challenge the three main biological markers used for the diagnosis of nitrous oxide abuse as total vitamin B12, homocysteine, and methylmalonic acid. Methods We retrospectively collected clinical and biological data from 52 patients with known, documented chronic N2O abuse and associated clinical signs (peripheral neuropathy disability score or thrombosis event). Sera and plasma total vitamin B12, methylmalonic acid (MMA), and homocysteine were performed to identify the most specific marker of chronic N2O intoxication and related clinical outcomes. Results Plasma homocysteine was almost consistently increased in case of N2O chronic consumption, whereas MMA increase and total vitamin B12 decrease are not systematically found. Our results showed that none of the markers are correlated with levels of N2O consumptions. However, homocysteine and MMA are correlated with clinical severity, but MMA seems to be a better marker of clinical severity. Conclusion There is no specific marker of nitrous oxide abuse according to levels of consumption, total vitamin B12 decrease could not be used either as consumption or as severity marker. However, we showed that homocysteine is consistently increased and could be used as marker of recent N2O consumption. On the other hand, we showed that MMA could be used as a marker of clinical gravity.Lire moins >
Lire la suite >Background Recreational use of nitrous oxide (N2O) leads to neurological disorders including combined subacute degeneration of spinal cord, psychological disorders, and thrombosis. Serum or urine N2O assays could not be routinely performed. Hence, it is necessary to investigate other biological markers such as metabolic markers. We aimed here to challenge the three main biological markers used for the diagnosis of nitrous oxide abuse as total vitamin B12, homocysteine, and methylmalonic acid. Methods We retrospectively collected clinical and biological data from 52 patients with known, documented chronic N2O abuse and associated clinical signs (peripheral neuropathy disability score or thrombosis event). Sera and plasma total vitamin B12, methylmalonic acid (MMA), and homocysteine were performed to identify the most specific marker of chronic N2O intoxication and related clinical outcomes. Results Plasma homocysteine was almost consistently increased in case of N2O chronic consumption, whereas MMA increase and total vitamin B12 decrease are not systematically found. Our results showed that none of the markers are correlated with levels of N2O consumptions. However, homocysteine and MMA are correlated with clinical severity, but MMA seems to be a better marker of clinical severity. Conclusion There is no specific marker of nitrous oxide abuse according to levels of consumption, total vitamin B12 decrease could not be used either as consumption or as severity marker. However, we showed that homocysteine is consistently increased and could be used as marker of recent N2O consumption. On the other hand, we showed that MMA could be used as a marker of clinical gravity.Lire moins >
Langue :
Anglais
Comité de lecture :
Oui
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Université de Lille
CHU Lille
CHU Lille
Collections :
Date de dépôt :
2023-06-05T06:50:15Z
2024-04-18T09:06:13Z
2024-04-18T09:07:10Z
2024-04-18T09:06:13Z
2024-04-18T09:07:10Z