Titre :

Mucoepidermoid carcinoma of salivary glands: A French Network of Rare Head and Neck Tumors (REFCOR) prospective study of 292 cases.

Auteur(s) :

Dahan, L. S. [Auteur]
Hôpital de la Conception [CHU - APHM] [LA CONCEPTION]
Giorgi, Roch [Auteur]
Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale [SESSTIM - U912 INSERM - Aix Marseille Univ - IRD]
Hôpital de la Timone [CHU - APHM] [TIMONE]
Vergez, Sebastien [Auteur]
Service Oto-Rhino-Laryngologie (ORL) et chirurgie cervico-faciale [CHU Toulouse]
Le Taillandier De Gabory, L. [Auteur]

Costes-Martineau, V. [Auteur]
Hôpital Gui de Chauliac [CHU Montpellier]
Herman, Philippe [Auteur]
Service d'oto-rhino-laryngologie
Hôpital Lariboisière
Poissonnet, G. [Auteur]
Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] [UNICANCER/CAL]
Mauvais, O. [Auteur]
Service ORL - Audiophonologie - Chirurgie cervico-faciale [Besançon]
Malard, O. [Auteur]
Service d'ORL
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Garrel, R. [Auteur]
Service ORL [Hôpital Gui de Chauliac] [CHRU de Montpellier]
Uro-Coste, E. [Auteur]
Service Anatomie et cytologie pathologiques [CHU Toulouse]
Barry, B. [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Bach, C. [Auteur]
Réseau d’Expertise Français sur les Cancers ORL Rares - French Network of Rare Head and Neck Tumors [REFCOR]
Hôpital Foch [Suresnes]
Chevalier, Dominique [Auteur]
Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277
Mouawad, Francois [Auteur]
Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277
Merol, J. C. [Auteur]
Hôpital universitaire Robert Debré [Reims] [CHU Reims]
Bastit, V. [Auteur]
Chirurgie ORL et cervico-faciale [Centre François Baclesse]
Thariat, J. [Auteur]
Centre Régional de Lutte contre le Cancer François Baclesse [Caen] [UNICANCER/CRLC]
Gilain, Laurent [Auteur]
Service ORL - Chirurgie Cervico-Faciale [CHU Clermont-Ferrand]
Dufour, X. [Auteur]
Centre hospitalier universitaire de Poitiers = Poitiers University Hospital [CHU de Poitiers [La Milétrie]]
Righini, C. A. [Auteur]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Service d'ORL et de chirurgie cervicale
Moya-Plana, Antoine [Auteur]
Institut Gustave Roussy [IGR]
Even, C. [Auteur]
Institut Gustave Roussy [IGR]
Radulesco, T. [Auteur]
Service d'Oto-rhino-laryngologie et Chirurgie cervico-faciale [Hôpital de la Conception - APHM]
Michel, J. [Auteur]
Hôpital de la Conception [CHU - APHM] [LA CONCEPTION]
Baujat, B. [Auteur]
CHU Tenon [AP-HP]
Fakhry, N. [Auteur]
Service d'Oto-rhino-laryngologie et Chirurgie cervico-faciale [Hôpital de la Conception - APHM]

Titre de la revue :

Eur J Surg Oncol

Nom court de la revue :

Eur J Surg Oncol

Date de publication :

2020-12-08

ISSN :

1532-2157

Mot(s)-clé(s) en anglais :

Salivary glands
Cancer
Parotid gland
Mucoepidermoid carcinoma

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background To describe the characteristics of the largest European study of MEC of salivary glands and to determine the prognostic factors for overall and disease free survival. Patients and methods Patients with MEC ...
Lire la suite >Background To describe the characteristics of the largest European study of MEC of salivary glands and to determine the prognostic factors for overall and disease free survival. Patients and methods Patients with MEC were prospectively included in the Réseau d’Expertise Français sur les Cancers ORL Rares (REFCOR, French Network of Rare Head and Neck Tumors) database between 2009 and 2015. Results A total of 292 patients were included. Tumors were classified as low grade in 175 cases (60%), intermediate in 39 (13%) and high grade in 78 (27%). Median follow-up was 26 months. The 5-year OS and DFS rates were respectively 83% and 69%. In multivariate analysis, age (p = 0.004), diabetes (p = 0.02) and advanced stage (p = 0.03) were found to have a significant negative impact on OS. Diabetes (p = 0.001), alcohol consumption (p = 0.003) and advanced stage (p = 0.001) were found to have a significant negative impact on DFS. Compare to low grade, high grade tended to have a negative impact on OS (p = 0.05) and had a significant effect on DFS (0.002) while intermediate grade had no significant influence on survival. The surgical treatment had a positive impact on both OS (p = 0.00005) and DFS (p = 0.0005). Postoperative radiotherapy had no impact in multivariate analysis. Conclusion Advanced clinical stage, high grade tumor, high age, the impossibility of carrying out a complete surgical resection, and diabetes are the main prognostic factors in this prospective series of patients with MEC. Such findings open new research perspectives on the influence of these components on initial patient care.Lire moins >

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277
• Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192

Date de dépôt :

2023-12-13T05:10:19Z
2024-02-01T08:43:24Z