Post-operative complications in elderly onset inflammatory bowel disease: a population-based study

Sacleux, S.-C.; Sarter, Helene; Fumery, M.; Charpentier, Cloe; Guillon, Nathalie; Coevoet, H.; Pariente, Benjamin; Peyrin-Biroulet, Laurent; Gower, Corinne; Savoye, Guillaume

Type de document :

Article dans une revue scientifique: Article original

DOI :

10.1111/apt.14790

PMID :

29737553

URL permanente :

http://hdl.handle.net/20.500.12210/104798

Titre :

Post-operative complications in elderly onset inflammatory bowel disease: a population-based study

Auteur(s) :

Sacleux, S.-C. [Auteur]
Sarter, Helene [Auteur]

Fumery, M. [Auteur]
Charpentier, Cloe [Auteur]
Guillon, Nathalie [Auteur]

Coevoet, H. [Auteur]
Pariente, Benjamin [Auteur]

Peyrin-Biroulet, Laurent [Auteur]
Gower, Corinne [Auteur]

Savoye, Guillaume [Auteur]

Titre de la revue :

ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Nom court de la revue :

Aliment. Pharmacol. Ther.

Date de publication :

2018-05-08

ISSN :

1365-2036

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

IBD diagnosed after the age of 60 is increasing. Data on post-operative complications in elderly onset IBD are scarce. To describe the incidence of and factors associated with post-operative complications in elderly onset ...
Lire la suite >IBD diagnosed after the age of 60 is increasing. Data on post-operative complications in elderly onset IBD are scarce. To describe the incidence of and factors associated with post-operative complications in elderly onset IBD, diagnosed after the age of 60. Using EPIMAD Cohort (1988-2006), among 841 incident IBD patients, 139 (17%) underwent intestinal surgery, including 100 Crohn's disease (CD) and 39 ulcerative colitis (UC). After a median post-operative follow-up of 6 years (2-10), 50 (36%) patients experienced at least 1 complication with a total of 69. During the first 30 post-operative days, the mortality rate was 4%. Thirty-two early complications (<30 days) were observed in 23 patients (17%), with 15 infectious, without significant difference between CD and UC. More than half early post-operative complications (n = 19, 59%) were severe (>grade 2) without significant difference between CD and UC (P = 0.28). Thirty-seven long-term adverse effects of surgical therapy (≥30 days) were observed in 33 patients (24%). Multivariate analysis found (1) acute severe colitis (OR = 7.84 [2.15-28.52]) and emergency surgery (OR = 4.46 [1.75-11.36]) were associated with early post-operative complications, and (2) Female gender (HR = 2.10 [1.01-4.37]) and delay before surgery >3 months (HR = 2.09 [1.01-4.31]) with long-term adverse effects of surgical therapy. One-third of elderly IBD patients experienced at least 1 post-operative complication. Half of the early complications were severe, and infectious. Emergency surgery was the key driver for post-operative complication.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Inserm
Université de Lille

Collections :

Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Date de dépôt :

2024-01-30T10:26:32Z

Numéro de version	Lien	Date de modification
2	20.500.12210/104798	2024-03-07T13:05:46Z
1	20.500.12210/104798.1*	2024-01-30T10:26:32Z

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