Title :

Synthesis and biological evaluation of ferrocene-based cannabinoid receptor 2 ligands

Author(s) :

Sansook, Supojjanee [Auteur]
Tuo, Wei [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Bollier, Melanie [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Barczyk, Amélie [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Dezitter, Xavier [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Klupsch, Frederique [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Chavain, Natascha [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Farce, Amaury [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Tizzard, Graham J. [Auteur]
Coles, Simon J. [Auteur]
Spencer, John [Auteur]
Millet, Régis [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]

Journal title :

Future Medicinal Chemistry

Abbreviated title :

Future Med Chem

Volume number :

10

Publication date :

2018-03

ISSN :

1756-8927

English keyword(s) :

isoxazole
cannabinoids
FAAH
ferrocene

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Ferrocene analogs of known fatty acid amide hydrolase inhibitors and CB2 ligands have been synthesized and characterized spectroscopically and crystallographically. The resulting bio-organometallic isoxazoles were assayed ...
Show more >Ferrocene analogs of known fatty acid amide hydrolase inhibitors and CB2 ligands have been synthesized and characterized spectroscopically and crystallographically. The resulting bio-organometallic isoxazoles were assayed for their effects on CB1 and CB2 receptors as well as on fatty acid amide hydrolase. None had any fatty acid amide hydrolase activity but compound 3, 5-(2-(pentyloxy)phenyl)-N-ferrocenylisoxazole-3-carboxamide, was found to be a potent CB2 ligand (Ki = 32.5 nM).Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-30T10:27:24Z
2024-03-18T13:38:36Z