Efficacy and safety of the local application ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
Efficacy and safety of the local application of mitomycin c to recurrent oesophageal strictures in children
Author(s) :
Ley, Delphine [Auteur]
Bridenne, Marie [Auteur]
Gottrand, fréderic [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Lemale, Julie [Auteur]
Hauser, Bruno [Auteur]
Lachaux, Alain [Auteur]
Rebouissoux, Laurent [Auteur]
Viala, Jerome [Auteur]
Fayoux, Pierre [Auteur]
Environnement Périnatal et Santé - EA 4489
Michaud, Laurent [Auteur]
Bridenne, Marie [Auteur]
Gottrand, fréderic [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Lemale, Julie [Auteur]
Hauser, Bruno [Auteur]
Lachaux, Alain [Auteur]
Rebouissoux, Laurent [Auteur]
Viala, Jerome [Auteur]
Fayoux, Pierre [Auteur]
Environnement Périnatal et Santé - EA 4489
Michaud, Laurent [Auteur]
Journal title :
Journal of Pediatric Gastroenterology and Nutrition
Abbreviated title :
J. Pediatr. Gastroenterol. Nutr.
Volume number :
69
Pages :
528-532
Publication date :
2019-07-10
ISSN :
1536-4801
English keyword(s) :
recurrent esophageal strictures
mitomycin C
esophageal atresia
caustic ingestion
mitomycin C
esophageal atresia
caustic ingestion
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Research on long-term use of mitomycin C (MC) for recurrent esophageal stenoses is limited. We assessed the long-term efficacy and safety of local application of MC for recurrent esophageal stenoses in children.
This was ...
Show more >Research on long-term use of mitomycin C (MC) for recurrent esophageal stenoses is limited. We assessed the long-term efficacy and safety of local application of MC for recurrent esophageal stenoses in children. This was a retrospective study of 39 patients (17 girls) with a median age of 19.5 months (range: 2.4-196.0) at the time of MC application. The etiologies of stenosis were esophageal atresia (n = 25), caustic ingestion (n = 9), congenital esophageal stenosis (n = 3), and other causes (n = 2). Stenosis was single in 35 (90%) patients and multiple in 4 (10%). Before MC, patients underwent multiple repeated dilations (median: 3 dilations per child [range: 2-26]) over a median period of 7 months (range: 2.6-49.3). Treatment success was defined a priori as a reduction in the number of dilations over the same period from before to after the application of MC. For 26 (67%) patients, the application of MC was considered a success: 102 versus 17 dilatations (P < 0.0001). Sixteen (41%) patients never required additional dilation during the follow-up after MC application (median: 3.1 years [range: 0.6-8.5]). No complication related to MC was observed. Biopsies at the site of MC application were performed at maximal follow-up in 16 patients and revealed no dysplasia. Three factors were associated with success of MC: single stenosis, short stenosis, and esophageal atresia type III. This study is the largest series reported showing that topical application of MC is an efficient and safe treatment for recurrent esophageal stenosis in children.Show less >
Show more >Research on long-term use of mitomycin C (MC) for recurrent esophageal stenoses is limited. We assessed the long-term efficacy and safety of local application of MC for recurrent esophageal stenoses in children. This was a retrospective study of 39 patients (17 girls) with a median age of 19.5 months (range: 2.4-196.0) at the time of MC application. The etiologies of stenosis were esophageal atresia (n = 25), caustic ingestion (n = 9), congenital esophageal stenosis (n = 3), and other causes (n = 2). Stenosis was single in 35 (90%) patients and multiple in 4 (10%). Before MC, patients underwent multiple repeated dilations (median: 3 dilations per child [range: 2-26]) over a median period of 7 months (range: 2.6-49.3). Treatment success was defined a priori as a reduction in the number of dilations over the same period from before to after the application of MC. For 26 (67%) patients, the application of MC was considered a success: 102 versus 17 dilatations (P < 0.0001). Sixteen (41%) patients never required additional dilation during the follow-up after MC application (median: 3.1 years [range: 0.6-8.5]). No complication related to MC was observed. Biopsies at the site of MC application were performed at maximal follow-up in 16 patients and revealed no dysplasia. Three factors were associated with success of MC: single stenosis, short stenosis, and esophageal atresia type III. This study is the largest series reported showing that topical application of MC is an efficient and safe treatment for recurrent esophageal stenosis in children.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Université de Lille
Université de Lille
Submission date :
2024-01-30T10:28:16Z
2024-02-06T11:26:21Z
2024-02-06T11:26:21Z