Efficacy and safety of the local application of mitomycin c to recurrent oesophageal strictures in children

Ley, Delphine; Bridenne, Marie; gottrand, Fréderic; Lemale, Julie; Hauser, Bruno; Lachaux, Alain; Rebouissoux, Laurent; Viala, Jerome; Fayoux, Pierre; Michaud, Laurent

Type de document :

Article dans une revue scientifique: Article original

DOI :

10.1097/MPG.0000000000002445

PMID :

31436711

URL permanente :

http://hdl.handle.net/20.500.12210/104993

Titre :

Efficacy and safety of the local application of mitomycin c to recurrent oesophageal strictures in children

Auteur(s) :

Ley, Delphine [Auteur]
Bridenne, Marie [Auteur]
gottrand, Fréderic [Auteur]

Lille Inflammation Research International Center (LIRIC) - U995
Lemale, Julie [Auteur]
Hauser, Bruno [Auteur]
Lachaux, Alain [Auteur]
Rebouissoux, Laurent [Auteur]
Viala, Jerome [Auteur]
Fayoux, Pierre [Auteur]

Environnement Périnatal et Santé - EA 4489
Michaud, Laurent [Auteur]

Titre de la revue :

Journal of Pediatric Gastroenterology and Nutrition

Nom court de la revue :

J. Pediatr. Gastroenterol. Nutr.

Date de publication :

2019-07-10

ISSN :

1536-4801

Mot(s)-clé(s) en anglais :

recurrent esophageal strictures
mitomycin C
esophageal atresia
caustic ingestion

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Research on long-term use of mitomycin C (MC) for recurrent esophageal stenoses is limited. We assessed the long-term efficacy and safety of local application of MC for recurrent esophageal stenoses in children. This was ...
Lire la suite >Research on long-term use of mitomycin C (MC) for recurrent esophageal stenoses is limited. We assessed the long-term efficacy and safety of local application of MC for recurrent esophageal stenoses in children. This was a retrospective study of 39 patients (17 girls) with a median age of 19.5 months (range: 2.4-196.0) at the time of MC application. The etiologies of stenosis were esophageal atresia (n = 25), caustic ingestion (n = 9), congenital esophageal stenosis (n = 3), and other causes (n = 2). Stenosis was single in 35 (90%) patients and multiple in 4 (10%). Before MC, patients underwent multiple repeated dilations (median: 3 dilations per child [range: 2-26]) over a median period of 7 months (range: 2.6-49.3). Treatment success was defined a priori as a reduction in the number of dilations over the same period from before to after the application of MC. For 26 (67%) patients, the application of MC was considered a success: 102 versus 17 dilatations (P < 0.0001). Sixteen (41%) patients never required additional dilation during the follow-up after MC application (median: 3.1 years [range: 0.6-8.5]). No complication related to MC was observed. Biopsies at the site of MC application were performed at maximal follow-up in 16 patients and revealed no dysplasia. Three factors were associated with success of MC: single stenosis, short stenosis, and esophageal atresia type III. This study is the largest series reported showing that topical application of MC is an efficient and safe treatment for recurrent esophageal stenosis in children.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Université de Lille

Collections :

Date de dépôt :

2024-01-30T10:28:16Z

Numéro de version	Lien	Date de modification
2	20.500.12210/104993	2024-02-06T11:23:03Z
1	20.500.12210/104993.1*	2024-01-30T10:28:16Z

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Efficacy and safety of the local application ...

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