Titre :

Racial differences in systemic sclerosis disease presentation: a european scleroderma trials and research group study

Auteur(s) :

Jaeger, Veronika K. [Auteur]
Tikly, Mohammed [Auteur]
Xu, Dong [Auteur]
Siegert, Elise [Auteur]
Hachulla, Eric [Auteur]
Centre National de Référence des Maladies Auto-Immunes Systémiques Rares du Nord et Nord-Ouest de France [CeRAINO]
Lille Inflammation Research International Center - U 995 [LIRIC]
Airo, Paolo [Auteur]
Valentini, Gabriele [Auteur]
Matucci-Cerinic, Marco [Auteur]
Distler, Oliver [Auteur]
Cozzi, Franco [Auteur]
Carreira, Patricia E. [Auteur]
Allanore, Yannick [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Muller-Ladner, Ulf [Auteur]
Ananieva, Lidia P. [Auteur]
Balbir-Gurman, Alexandra [Auteur]
Distler, Jorg H. W. [Auteur]
Czirjak, Laszlo [Auteur]
Li, Mengtao [Auteur]
Henes, Jorg [Auteur]
Jimenez, Sergio A. [Auteur]
Smith, Vanessa [Auteur]
Damjanov, Nemanja [Auteur]
Denton, Christopher P. [Auteur]
Del Galdo, Francesco [Auteur]
Saketkoo, Lesley Ann [Auteur]
Walker, Ulrich A. [Auteur]

Titre de la revue :

Rheumatology

Nom court de la revue :

Rheumatology (Oxford)

Numéro :

59

Date de publication :

2020-07

ISSN :

1462-0332

Mot(s)-clé(s) en anglais :

races
organ manifestations
systemic sclerosis

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

OBJECTIVE: Racial factors play a significant role in SSc. We evaluated differences in SSc presentations between white patients (WP), Asian patients (AP) and black patients (BP) and analysed the effects of geographical ...
Lire la suite >OBJECTIVE: Racial factors play a significant role in SSc. We evaluated differences in SSc presentations between white patients (WP), Asian patients (AP) and black patients (BP) and analysed the effects of geographical locations. METHODS: SSc characteristics of patients from the EUSTAR cohort were cross-sectionally compared across racial groups using survival and multiple logistic regression analyses. RESULTS: The study included 9162 WP, 341 AP and 181 BP. AP developed the first non-RP feature faster than WP but slower than BP. AP were less frequently anti-centromere (ACA; odds ratio (OR) = 0.4, P < 0.001) and more frequently anti-topoisomerase-I autoantibodies (ATA) positive (OR = 1.2, P = 0.068), while BP were less likely to be ACA and ATA positive than were WP [OR(ACA) = 0.3, P < 0.001; OR(ATA) = 0.5, P = 0.020]. AP had less often (OR = 0.7, P = 0.06) and BP more often (OR = 2.7, P < 0.001) diffuse skin involvement than had WP. AP and BP were more likely to have pulmonary hypertension [OR(AP) = 2.6, P < 0.001; OR(BP) = 2.7, P = 0.03 vs WP] and a reduced forced vital capacity [OR(AP) = 2.5, P < 0.001; OR(BP) = 2.4, P < 0.004] than were WP. AP more often had an impaired diffusing capacity of the lung than had BP and WP [OR(AP vs BP) = 1.9, P = 0.038; OR(AP vs WP) = 2.4, P < 0.001]. After RP onset, AP and BP had a higher hazard to die than had WP [hazard ratio (HR) (AP) = 1.6, P = 0.011; HR(BP) = 2.1, P < 0.001]. CONCLUSIONS: Compared with WP, and mostly independent of geographical location, AP have a faster and earlier disease onset with high prevalences of ATA, pulmonary hypertension and forced vital capacity impairment and higher mortality. BP had the fastest disease onset, a high prevalence of diffuse skin involvement and nominally the highest mortality.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Date de dépôt :

2024-01-30T10:28:31Z
2024-04-25T13:47:31Z