Title :

Four cancer cases after esophageal atresia repair: Time to start screening the upper gastrointestinal tract

Author(s) :

Vergouwe, F. W. T. [Auteur]
Erasmus University Medical Center [Rotterdam] [Erasmus MC]
Gottrand, Madeleine [Auteur]
Hôpital Jeanne de Flandre [Lille]
Lille Inflammation Research International Center - U 995 [LIRIC]
Wijnhoven, B. P. L. [Auteur]
Erasmus University Medical Center [Rotterdam] [Erasmus MC]
Ijsselstijn, H. [Auteur]
Erasmus University Medical Center [Rotterdam] [Erasmus MC]
Piessen, Guillaume [Auteur]
Hôpital Claude Huriez [Lille]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172
Bruno, M. J. [Auteur]
Erasmus University Medical Center [Rotterdam] [Erasmus MC]
Wijnen, R. M. H. [Auteur]
Erasmus University Medical Center [Rotterdam] [Erasmus MC]
Spaander, M. C. W. [Auteur]
Erasmus University Medical Center [Rotterdam] [Erasmus MC]

Journal title :

World Journal of Gastroenterology

Abbreviated title :

World J. Gastroenterol.

Volume number :

24

Pages :

1056-1062

Publication date :

2018-03-17

ISSN :

1007-9327

English keyword(s) :

Adenocarcinoma
Esophageal atresia
Esophageal cancer
Screening
Barrett's esophagus
Squamous cell carcinoma

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Esophageal atresia (EA) is one of the most common congenital digestive malformations and requires surgical correction early in life. Dedicated centers have reported survival rates up to 95%. The most frequent comorbidities ...
Show more >Esophageal atresia (EA) is one of the most common congenital digestive malformations and requires surgical correction early in life. Dedicated centers have reported survival rates up to 95%. The most frequent comorbidities after EA repair are dysphagia (72%) and gastroesophageal reflux (GER) (67%). Chronic GER after EA repair might lead to mucosal damage, esophageal stricturing, Barrett’s esophagus and eventually esophageal adenocarcinoma. Several long-term follow-up studies found an increased risk of Barrett’s esophagus and esophageal carcinoma in EA patients, both at a relatively young age. Given these findings, the recent ESPGHAN-NASPGHAN guideline recommends routine endoscopy in adults born with EA. We report a series of four EA patients who developed a carcinoma of the gastrointestinal tract: three esophageal carcinoma and one colorectal carcinoma in a colonic interposition. These cases emphasize the importance of lifelong screening of the upper gastrointestinal tract in EA patients.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277
• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-02-03T22:41:31Z
2024-02-29T08:21:14Z