Title :

Mucin CYS domains are ancient and highly conserved modules that evolved in concert.

Author(s) :

Desseyn, Jean-Luc [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]

Journal title :

Molecular Phylogenetics and Evolution

Abbreviated title :

Mol Phylogenet Evol

Volume number :

52

Pages :

284-92

Publication date :

2009-08-01

ISSN :

1095-9513

English keyword(s) :

Animals
Conserved Sequence
Cysteine
Evolution
Molecular
Exons
Humans
Mucins
Phylogeny
Protein Interaction Domains and Motifs
Sequence Alignment
Sequence Analysis
DNA

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Many large secreted gel-forming mucins contain multiple copies of a "naked" cysteine-enriched domain (CYS domain) that interrupt or are adjacent to mucin domains (Ser/Thr/Pro regions). There is less similarity of homologous ...
Show more >Many large secreted gel-forming mucins contain multiple copies of a "naked" cysteine-enriched domain (CYS domain) that interrupt or are adjacent to mucin domains (Ser/Thr/Pro regions). There is less similarity of homologous CYS sequences between species than there is across CYS repeats within species. These CYS domains are likely implicated in reversible mucin-mucin interactions that play a central role in mucus properties. The use of multiple genome sequences in a comparative analysis of CYS sequences identified new mucins containing the CYS domain in various species. Furthermore, analysis showed that this domain is at least 650 million-year old and that CYS sequences evolved under strong selective pressure in concerted fashion in all species examined by two mechanisms that never coexist within a given gene: either multiplication of exons encoding CYS modules or successive intra-exonic duplications. The CYS sequences appear to have undergone concerted evolution with a high selective pressure to conserve cysteine and other amino acid residues. This domain is the best-conserved domain in secreted mucins pointing toward an important common function in many different organisms.Show less >

Language :

Anglais

Audience :

Non spécifiée

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Research team(s) :

Nutritional modulation of inflammation and infection

Submission date :

2019-07-04T14:56:12Z
2019-07-08T13:51:08Z