Mucin CYS domains are ancient and highly ...
Document type :
Article dans une revue scientifique
PMID :
Permalink :
Title :
Mucin CYS domains are ancient and highly conserved modules that evolved in concert.
Author(s) :
Journal title :
Molecular Phylogenetics and Evolution
Abbreviated title :
Mol Phylogenet Evol
Volume number :
52
Pages :
284-92
Publication date :
2009-08-01
ISSN :
1095-9513
English keyword(s) :
Animals
Conserved Sequence
Cysteine
Evolution
Molecular
Exons
Humans
Mucins
Phylogeny
Protein Interaction Domains and Motifs
Sequence Alignment
Sequence Analysis
DNA
Conserved Sequence
Cysteine
Evolution
Molecular
Exons
Humans
Mucins
Phylogeny
Protein Interaction Domains and Motifs
Sequence Alignment
Sequence Analysis
DNA
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Many large secreted gel-forming mucins contain multiple copies of a "naked" cysteine-enriched domain (CYS domain) that interrupt or are adjacent to mucin domains (Ser/Thr/Pro regions). There is less similarity of homologous ...
Show more >Many large secreted gel-forming mucins contain multiple copies of a "naked" cysteine-enriched domain (CYS domain) that interrupt or are adjacent to mucin domains (Ser/Thr/Pro regions). There is less similarity of homologous CYS sequences between species than there is across CYS repeats within species. These CYS domains are likely implicated in reversible mucin-mucin interactions that play a central role in mucus properties. The use of multiple genome sequences in a comparative analysis of CYS sequences identified new mucins containing the CYS domain in various species. Furthermore, analysis showed that this domain is at least 650 million-year old and that CYS sequences evolved under strong selective pressure in concerted fashion in all species examined by two mechanisms that never coexist within a given gene: either multiplication of exons encoding CYS modules or successive intra-exonic duplications. The CYS sequences appear to have undergone concerted evolution with a high selective pressure to conserve cysteine and other amino acid residues. This domain is the best-conserved domain in secreted mucins pointing toward an important common function in many different organisms.Show less >
Show more >Many large secreted gel-forming mucins contain multiple copies of a "naked" cysteine-enriched domain (CYS domain) that interrupt or are adjacent to mucin domains (Ser/Thr/Pro regions). There is less similarity of homologous CYS sequences between species than there is across CYS repeats within species. These CYS domains are likely implicated in reversible mucin-mucin interactions that play a central role in mucus properties. The use of multiple genome sequences in a comparative analysis of CYS sequences identified new mucins containing the CYS domain in various species. Furthermore, analysis showed that this domain is at least 650 million-year old and that CYS sequences evolved under strong selective pressure in concerted fashion in all species examined by two mechanisms that never coexist within a given gene: either multiplication of exons encoding CYS modules or successive intra-exonic duplications. The CYS sequences appear to have undergone concerted evolution with a high selective pressure to conserve cysteine and other amino acid residues. This domain is the best-conserved domain in secreted mucins pointing toward an important common function in many different organisms.Show less >
Language :
Anglais
Audience :
Non spécifiée
Research team(s) :
Nutritional modulation of inflammation and infection
Submission date :
2019-07-04T14:56:12Z
2019-07-08T13:51:08Z
2019-07-08T13:51:08Z
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