Titre :

Mucin CYS domains are ancient and highly conserved modules that evolved in concert.

Auteur(s) :

Desseyn, Jean-Luc [Auteur]

Titre de la revue :

Molecular Phylogenetics and Evolution

Nom court de la revue :

Mol Phylogenet Evol

Numéro :

52

Pagination :

284-92

Date de publication :

2009-08-01

ISSN :

1095-9513

Mot(s)-clé(s) en anglais :

Animals
Conserved Sequence
Cysteine
Evolution
Molecular
Exons
Humans
Mucins
Phylogeny
Protein Interaction Domains and Motifs
Sequence Alignment
Sequence Analysis
DNA

Résumé en anglais : [en]

Many large secreted gel-forming mucins contain multiple copies of a "naked" cysteine-enriched domain (CYS domain) that interrupt or are adjacent to mucin domains (Ser/Thr/Pro regions). There is less similarity of homologous ...
Lire la suite >Many large secreted gel-forming mucins contain multiple copies of a "naked" cysteine-enriched domain (CYS domain) that interrupt or are adjacent to mucin domains (Ser/Thr/Pro regions). There is less similarity of homologous CYS sequences between species than there is across CYS repeats within species. These CYS domains are likely implicated in reversible mucin-mucin interactions that play a central role in mucus properties. The use of multiple genome sequences in a comparative analysis of CYS sequences identified new mucins containing the CYS domain in various species. Furthermore, analysis showed that this domain is at least 650 million-year old and that CYS sequences evolved under strong selective pressure in concerted fashion in all species examined by two mechanisms that never coexist within a given gene: either multiplication of exons encoding CYS modules or successive intra-exonic duplications. The CYS sequences appear to have undergone concerted evolution with a high selective pressure to conserve cysteine and other amino acid residues. This domain is the best-conserved domain in secreted mucins pointing toward an important common function in many different organisms.Lire moins >

Audience :

Non spécifiée

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Équipe(s) de recherche :

Nutritional modulation of inflammation and infection

Date de dépôt :

2019-07-04T14:56:12Z