Architecture of the gel-forming mucins
Document type :
Partie d'ouvrage: Chapitre
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Title :
Architecture of the gel-forming mucins
Author(s) :
Desseyn, Jean-Luc [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Gouyer, Valérie [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Tetaert, Daniel [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]
Lille Inflammation Research International Center - U 995 [LIRIC]
Gouyer, Valérie [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Tetaert, Daniel [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]
Book title :
The Epithelial Mucins: Structure/Function. Roles in Cancer and Inflammatory Diseases
Pages :
1-16
Publisher :
Isabelle Van Seuningen/Research Signpost
Publication place :
Kerala
India
India
Publication date :
2008
ISBN :
978-81-308-0256-5
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
This review article focuses on the multi-domain
organization of the five human gel-forming mucins
MUC2, MUC5B, MUC5AC, MUC6 and MUC19. Gel-
forming mucins are O-glycoproteins with high
molecular mass that are secreted ...
Show more >This review article focuses on the multi-domain organization of the five human gel-forming mucins MUC2, MUC5B, MUC5AC, MUC6 and MUC19. Gel- forming mucins are O-glycoproteins with high molecular mass that are secreted at the cell surface of many secretory organs by specialized epithelial cells. They form dimers through their carboxy-termini regions and then multimers through their amino- termini regions before being secreted into the lumen of organs as long linear filaments. In addition, an overview of their genomic organization is given and we took the opportunity of this article to determine the genomic organisation of the 5'-end region of MUC5AC. Finally, we discuss the polymorphism of mucins and a few features of long messengers.Show less >
Show more >This review article focuses on the multi-domain organization of the five human gel-forming mucins MUC2, MUC5B, MUC5AC, MUC6 and MUC19. Gel- forming mucins are O-glycoproteins with high molecular mass that are secreted at the cell surface of many secretory organs by specialized epithelial cells. They form dimers through their carboxy-termini regions and then multimers through their amino- termini regions before being secreted into the lumen of organs as long linear filaments. In addition, an overview of their genomic organization is given and we took the opportunity of this article to determine the genomic organisation of the 5'-end region of MUC5AC. Finally, we discuss the polymorphism of mucins and a few features of long messengers.Show less >
Language :
Anglais
Audience :
Internationale
Administrative institution(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Collections :
Submission date :
2019-10-30T10:11:54Z
2019-10-31T09:31:49Z
2019-10-31T09:31:49Z
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