Architecture of the gel-forming mucins
Type de document :
Partie d'ouvrage: Chapitre
URL permanente :
Titre :
Architecture of the gel-forming mucins
Auteur(s) :
Titre de l’ouvrage :
The Epithelial Mucins: Structure/Function. Roles in Cancer and Inflammatory Diseases
Pagination :
1-16
Éditeur :
Isabelle Van Seuningen/Research Signpost
Lieu de publication :
Kerala
India
India
Date de publication :
2008
ISBN :
978-81-308-0256-5
Résumé en anglais : [en]
This review article focuses on the multi-domain
organization of the five human gel-forming mucins
MUC2, MUC5B, MUC5AC, MUC6 and MUC19. Gel-
forming mucins are O-glycoproteins with high
molecular mass that are secreted ...
Lire la suite >This review article focuses on the multi-domain organization of the five human gel-forming mucins MUC2, MUC5B, MUC5AC, MUC6 and MUC19. Gel- forming mucins are O-glycoproteins with high molecular mass that are secreted at the cell surface of many secretory organs by specialized epithelial cells. They form dimers through their carboxy-termini regions and then multimers through their amino- termini regions before being secreted into the lumen of organs as long linear filaments. In addition, an overview of their genomic organization is given and we took the opportunity of this article to determine the genomic organisation of the 5'-end region of MUC5AC. Finally, we discuss the polymorphism of mucins and a few features of long messengers.Lire moins >
Lire la suite >This review article focuses on the multi-domain organization of the five human gel-forming mucins MUC2, MUC5B, MUC5AC, MUC6 and MUC19. Gel- forming mucins are O-glycoproteins with high molecular mass that are secreted at the cell surface of many secretory organs by specialized epithelial cells. They form dimers through their carboxy-termini regions and then multimers through their amino- termini regions before being secreted into the lumen of organs as long linear filaments. In addition, an overview of their genomic organization is given and we took the opportunity of this article to determine the genomic organisation of the 5'-end region of MUC5AC. Finally, we discuss the polymorphism of mucins and a few features of long messengers.Lire moins >
Langue :
Anglais
Audience :
Internationale
Établissement(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Date de dépôt :
2019-10-30T10:11:54Z
Fichiers
- Desseyn_2008_ChptI.pdf
- Version éditeur
- Accès restreint 2079-12-31
- Accéder au document