Titre :

Association between acute graft pyelonephritis and kidney graft survival: a single-center observational study

Auteur(s) :

Maanaoui, Mehdi [Auteur]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Baes, Dulciane [Auteur]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Hamroun, Aghiles [Auteur]
Centre de recherche en épidémiologie et santé des populations [CESP]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Khedjat, Kahina [Auteur]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Vuotto, Fanny [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Faure, Emmanuel [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Lopez, Benjamin [Auteur]
Bouye, Sebastien [Auteur]
Service d'Urologie, andrologie et transplantation rénale [CHRU Lille]
Caes, Thomas [Auteur]
Service d'Urologie, andrologie et transplantation rénale [CHRU Lille]
Lionet, Arnaud [Auteur]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Lebas, Celine [Auteur]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Provot, Francois [Auteur]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Glowacki, Francois [Auteur]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Gibier, Jean-Baptiste [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172
Lenain, Remi [Auteur]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Hazzan, Marc [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Service de Néphrologie et Transplantation rénale [CHRU-lille]

Titre de la revue :

American Journal of Transplantation

Nom court de la revue :

Am J Transplant

Date de publication :

2021-05-31

ISSN :

1600-6143

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

The association between acute graft pyelonephritis (AGPN) and graft failure in kidney transplant recipients (KTR) remains controversial. In this single-center observational study, we aimed to assess the incidence of AGPN ...
Lire la suite >The association between acute graft pyelonephritis (AGPN) and graft failure in kidney transplant recipients (KTR) remains controversial. In this single-center observational study, we aimed to assess the incidence of AGPN as a time-dependent posttransplantation event. We also examined the association between the diagnosis of AGPN and graft outcomes. In total, we evaluated 1480 patients who underwent kidney transplantation between January 2007 and December 2017. During a median follow-up of 5.04 years, we observed 297 AGPN episodes that occurred in 158 KTR. To evaluate the association between AGPN and clinical outcomes, we performed Cox proportional hazards regression analyses in which AGPN was entered as a time-dependent covariate. AGPN was independently associated with an increased risk of graft loss (hazard ratio = 1.66; 95% confidence interval [CI]: 1.05–2.64, p < .03) and a persistently decreased eGFR (fixed effect on intercept: –2.29 ml/min/1.73 m2; 95% CI: from –3.23 to –1.35, p < .01). However, neither mortality nor biopsy-proven acute rejection was found to correlate with AGPN. Moreover, recurrent AGPN episodes did not appear to have an additive detrimental impact on graft loss. These data represent a promising step in understanding whether AGPN prevention may decrease the risk of graft loss in KTR.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Date de dépôt :

2021-07-06T12:44:14Z
2024-02-05T13:25:08Z