Titre :

Outcome of patients treated with molecular adsorbent recirculating system albumin dialysis: a national multicenter study

Auteur(s) :

Camus, Christophe [Auteur]
Locher, Clara [Auteur]
Saliba, Faouzi [Auteur]
Goubaux, Bernard [Auteur]
Bonadona, Agnes [Auteur]
Lavayssiere, Laurence [Auteur]
Paugam, Catherine [Auteur]
Quinart, Alice [Auteur]
Barbot, Olivier [Auteur]
Dharancy, Sebastien [Auteur]
Delafosse, Bertrand [Auteur]
Pichon, Nicolas [Auteur]
Barraud, Helene [Auteur]
Galbois, Arnaud [Auteur]
Veber, Benoit [Auteur]
Cayot, Sophie [Auteur]
Souche, Bruno [Auteur]

Nom court de la revue :

JGH Open

Date de publication :

2020-05-17

ISSN :

2397-9070

Mot(s)-clé(s) :

MARS albumin dialysis
liver transplantation
retrospective study
outcome

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

The molecular adsorbent recirculating system (MARS) is the most widely used device to treat liver failure. Nevertheless, data from widespread real-life use are lacking. This was a retrospective multicenter study conducted ...
Lire la suite >The molecular adsorbent recirculating system (MARS) is the most widely used device to treat liver failure. Nevertheless, data from widespread real-life use are lacking. This was a retrospective multicenter study conducted in all French adult care centers that used MARS between 2004 and 2009. The primary objective was to evaluate patient survival according to the liver disease and listing status. Factors associated with mortality were the secondary objectives. A total of 383 patients underwent 393 MARS treatments. The main indications were acute liver failure (ALF, 32.6%), and severe cholestasis (total bilirubin >340 μmol/L) (37.2%), hepatic encephalopathy (23.7%), and/or acute kidney injury-hepatorenal syndrome (22.9%) most often among patients with chronic liver disease. At the time of treatment, 34.4% of the patients were listed. Overall, the hospital survival rate was 49% (95% CI: 44-54%) and ranged from 25% to 81% depending on the diagnosis of the liver disease. In listed patients versusvsvsvsP Our study suggests that MARS should be mainly used as a bridge to liver transplantation. Survival was correlated with being listed for most etiologies and with the intensity of treatment in ALF.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Date de dépôt :

2021-07-06T12:47:10Z