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Septic Shock Shapes B Cell Response toward ...
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Document type :
Article dans une revue scientifique
DOI :
10.4049/jimmunol.1700929
PMID :
29459404
Permalink :
http://hdl.handle.net/20.500.12210/4647
Title :
Septic Shock Shapes B Cell Response toward an Exhausted-like/Immunoregulatory Profile in Patients.
Author(s) :
Gustave, Claude-Alexandre [Auteur]
Gossez, Morgane [Auteur]
Demaret, Julie [Auteur] refId
Lille Inflammation Research International Center (LIRIC) - U995
Rimmele, Thomas [Auteur]
Lepape, Alain [Auteur]
Malcus, Christophe [Auteur]
Poitevin-Later, Francoise [Auteur]
Jallades, Laurent [Auteur]
Textoris, Julien [Auteur]
Monneret, Guillaume [Auteur]
Venet, Fabienne [Auteur]
Journal title :
Journal of immunology
Abbreviated title :
J. Immunol.
Publication date :
2018-02-19
ISSN :
1550-6606
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Septic shock is accompanied by the development of immune dysfunctions whose intensity and duration are associated with increased risk of secondary infections and mortality. Although B lymphocytes play a pivotal role in ...
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Septic shock is accompanied by the development of immune dysfunctions whose intensity and duration are associated with increased risk of secondary infections and mortality. Although B lymphocytes play a pivotal role in the immune response to infections, no comprehensive exploration of circulating B cell status has been performed during the immunosuppressive phase of septic shock. Thus, our aim was to extensively characterize the phenotype and function of B cells in septic shock, including IL-10 production. Circulating B lymphocyte phenotype and function were evaluated by flow cytometry on fresh whole blood and after ex vivo stimulation in adult septic shock patients sampled at day 1, 3, and 6 after the onset of shock. The circulating B cell number was reduced in septic shock patients, whereas the B cell proportion among total lymphocytes was increased. The remaining circulating B lymphocytes presented with decreased MHC class II expression and increased CD21(low) CD95(high) exhausted-like phenotype but showed no change in maturation status. Circulating B cell functions were markedly altered after sepsis with reduced ex vivo activation and proliferation capacities. Finally, B cell response after septic shock was characterized by a clear plasmacytosis and an increased IL-10 production in remaining B cells from patients after ex vivo stimulation. During the sepsis-induced immunosuppression phase, B cell response is altered and is oriented toward an exhausted-like/immunoregulatory profile. Further studies are now needed to confirm the immunoregulatory properties of B lymphocytes and evaluate their role in sepsis-induced immunosuppression.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Inserm
Université de Lille
CHU Lille
Collections :
  • Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Research team(s) :
Immunity, inflammation and fibrsis in auto and allo-reactivity
Submission date :
2019-03-01T14:17:57Z
Université de Lille

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