Septic Shock Shapes B Cell Response toward an Exhausted-like/Immunoregulatory Profile in Patients.

Gustave, Claude-Alexandre; Gossez, Morgane; Demaret, Julie; Rimmele, Thomas; Lepape, Alain; Malcus, Christophe; Poitevin-Later, Francoise; Jallades, Laurent; Textoris, Julien; Monneret, Guillaume; Venet, Fabienne

Type de document :

Article dans une revue scientifique

DOI :

10.4049/jimmunol.1700929

PMID :

29459404

URL permanente :

http://hdl.handle.net/20.500.12210/4647

Titre :

Septic Shock Shapes B Cell Response toward an Exhausted-like/Immunoregulatory Profile in Patients.

Auteur(s) :

Gustave, Claude-Alexandre [Auteur]
Gossez, Morgane [Auteur]
Demaret, Julie [Auteur]

Lille Inflammation Research International Center - U 995 [LIRIC]
Lille Inflammation Research International Center (LIRIC) - U995
Rimmele, Thomas [Auteur]
Lepape, Alain [Auteur]
Malcus, Christophe [Auteur]
Poitevin-Later, Francoise [Auteur]
Jallades, Laurent [Auteur]
Textoris, Julien [Auteur]
Monneret, Guillaume [Auteur]
Venet, Fabienne [Auteur]

Titre de la revue :

Journal of immunology

Nom court de la revue :

J. Immunol.

Date de publication :

2018-02-19

ISSN :

1550-6606

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Septic shock is accompanied by the development of immune dysfunctions whose intensity and duration are associated with increased risk of secondary infections and mortality. Although B lymphocytes play a pivotal role in ...
Lire la suite >Septic shock is accompanied by the development of immune dysfunctions whose intensity and duration are associated with increased risk of secondary infections and mortality. Although B lymphocytes play a pivotal role in the immune response to infections, no comprehensive exploration of circulating B cell status has been performed during the immunosuppressive phase of septic shock. Thus, our aim was to extensively characterize the phenotype and function of B cells in septic shock, including IL-10 production. Circulating B lymphocyte phenotype and function were evaluated by flow cytometry on fresh whole blood and after ex vivo stimulation in adult septic shock patients sampled at day 1, 3, and 6 after the onset of shock. The circulating B cell number was reduced in septic shock patients, whereas the B cell proportion among total lymphocytes was increased. The remaining circulating B lymphocytes presented with decreased MHC class II expression and increased CD21(low) CD95(high) exhausted-like phenotype but showed no change in maturation status. Circulating B cell functions were markedly altered after sepsis with reduced ex vivo activation and proliferation capacities. Finally, B cell response after septic shock was characterized by a clear plasmacytosis and an increased IL-10 production in remaining B cells from patients after ex vivo stimulation. During the sepsis-induced immunosuppression phase, B cell response is altered and is oriented toward an exhausted-like/immunoregulatory profile. Further studies are now needed to confirm the immunoregulatory properties of B lymphocytes and evaluate their role in sepsis-induced immunosuppression.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Inserm
Université de Lille
CHU Lille

Collections :

Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Équipe(s) de recherche :

Immunity, inflammation and fibrsis in auto and allo-reactivity

Date de dépôt :

2019-03-01T14:17:57Z

Numéro de version	Lien	Date de modification
2	20.500.12210/4647	2024-04-08T07:56:11Z
1	20.500.12210/4647.1*	2019-03-01T14:17:57Z

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