Titre :

The prognostic impact of cirrhosis on patients receiving maintenance haemodialysis

Auteur(s) :

Artru, Florent [Auteur]
Louvet, Alexandre [Auteur]
Glowacki, Francois [Auteur]
Bellati, Sara [Auteur]
Frimat, Marie [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Gomis, Sebastien [Auteur]
Castel, Helene [Auteur]
Barthelon, Justine [Auteur]
Lassailly, Guillaume [Auteur]
Dharancy, Sebastien [Auteur]
Noel, Christian [Auteur]
Hazzan, Marc [Auteur]
Mathurin, Philippe [Auteur]

Titre de la revue :

Alimentary pharmacology & therapeutics

Nom court de la revue :

Aliment. Pharmacol. Ther.

Date de publication :

2019-05-14

ISSN :

1365-2036

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Further study is needed on the prognostic impact of cirrhosis on haemodialysis patients. To evaluate cirrhosis' impact according to severity on survival and to provide therapeutic guidelines for haemodialysis cirrhotic ...
Lire la suite >Further study is needed on the prognostic impact of cirrhosis on haemodialysis patients. To evaluate cirrhosis' impact according to severity on survival and to provide therapeutic guidelines for haemodialysis cirrhotic patients. Patients with end-stage renal failure treated with haemodialysis were included retrospectively from 01/01/2000 to 31/12/2004 and prospectively from 01/01/2005 to 31/12/2014 in our French Region. Clinical data, presence of cirrhosis and its severity were recorded at the beginning of haemodialysis. The primary endpoint was 2-year survival. Seven thousand three hundred and fifty-four patients (96%) without cirrhosis and 304 patients (4%) with cirrhosis were included. Two-year survival in noncirrhotic patients was higher than in cirrhotic patients (71.7% vs 54.4%, P < 0.0001). Patients with decompensated cirrhosis had a worse 2-year outcome (44.1%) as compared to compensated cirrhotic (62.8%, P = 0.002) and noncirrhotic patients (71.7%, P < 0.0001). Compensated and decompensated cirrhosis were independent predictive factors of 2-year mortality. In sensitivity analysis restricted to cirrhotic patients, 2-year survival of Child-Pugh A patients was higher than in Child-Pugh B and C patients (65.5% vs 27.7% vs 0%, P < 0.0001). Development of predictive models based either on severity scores (MELD and Child-Pugh) and extrahepatic comorbidities allowed correct classification of around 70% of patients in terms of mortality and may help to better stratify mortality risk in this population. Cirrhosis is independently associated with mortality in haemodialysis patients. Patients with severe cirrhosis have a poor 2-year outcome. Severity of cirrhosis and presence of extrahepatic comorbidities should be considered when deciding to initiate renal replacement therapy.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Inserm
Institut Pasteur de Lille
Université de Lille

Collections :

• Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Date de dépôt :

2022-02-02T10:23:22Z